Table 2.
Summary of studies on the anticancer prospects of endophytes.
| Endophytes | Compound secreted | Class of compound | Activity | Cell active against | References |
|---|---|---|---|---|---|
| Endophytic fungi | |||||
| Fusarium oxysporium | Vincristine | Alkaloids | Anticancer | – | Zhang et al., 2000 |
| Mycellia sterilia | Vincristine | Alkaloids | Anticancer | Yang et al., 2004 | |
| Enthrophospora infrequens | Camptothecin | Quinolone alkaloid | Anticancer | Puri et al., 2005 | |
| Phomopsis cassiae | 3,12-dihydroxydalene 3,12-dihydroxycalamenene 3,11,12-trihydroxycadalene | Terpenoids | Anti-proliferative | HeLa cervical cells | Silva et al., 2006 |
| Periconia atropurpurea | EtOAc extract | – | Cytotoxicity | – | Teles et al., 2006 |
| Garcinia sp. | EtOAc extract | – | Antiproliferative and cytotoxicity | Vero cell lines | Phongpaichit et al., 2007 |
| Collentotrichum gloesporiodes | Taxol | Alkaloids | Cytotoxicity | Human cancer cells lines BT220, int 407, H116, HLK 210, HL251. | Gangadevi and Muthumary, 2008 |
| Aspergillus fumigatus | Cytotoxic alkaloids | Alkaloids | Cytotoxicity | Leukemia cancer cell line | Konecny et al., 2009 |
| C. gloesporiodes | Taxol | Alkaloids | Anticancer | Nithya and Muthumary, 2009 | |
| Alternaria alternata | EtOAc extract | – | Antitumor and cytotoxicity | HeLa cells | Fernandes et al., 2009 |
| Alternaria sp. | Xanalteric acids | Phenols | Cytotoxicity | Kjer et al., 2009 | |
| Fusarium solani | Camptothecin | Quinolone alkaloid | Anticancer | – | Shweta et al., 2010 |
| Lasidiplodia theobromae | Taxol | Alkaloids | Anticancer | MCF-7 | Pandi et al., 2011 |
| Cephalotheca faveolata | Sclerotiorin | Polyketides | Anticancer | Colon cancer (HCT-116) | Giridharan et al., 2012 |
| Phoma sp. | 5-hydroxyramulosin | Polyketides | Anticancer | Santiago et al., 2012 | |
| Penicillium sp. | Arisugacin | Terpenoid derivatives | Anticancer | HeLa, HL-60, and K562 cell lines | Sun et al., 2014 |
| A. flavus | Solamargine | Steriods | Cytotoxicity | – | El-Hawary et al., 2016 |
| Taxomyces andreanae | Paclitaxel | Alkaloids | Anticancer | – | Alurappa et al., 2018 |
| Chaetomium sp., Alternaria sp., and Collentotrichum sp. | EtOAc extract | – | Cytotoxicity | HeLa and MCF-7 cells | Dhayanithy et al., 2019 |
| Endophytic actinomycetes | |||||
| Streptomyces thermoviolaceus TP-A0648 | Anicemycin | Alkaloids | Antitumor | – | Igarashi, 2004 |
| Streptomyces sp. SUC1 | Lansai A-D | Alkaloids | Anticancer | – | Tuntiwachwuttikul et al., 2008 |
| Actinosynnema pretiosum | Ansamitocin | Polyketides | Antitumor | – | Siyu-Mao, 2013 |
| Micromonospora lupini Lupac 08 | Lupinacidin C | Quinones | Antitumor | Murine colon carcinoma cells | Igarashi et al., 2011 |
| Streptomyces sp. CS | Naphtomycin A | Quinones | Antitumor | P388 and A-549 cell lines | Lu and Shen, 2007 |
| Streptomyces laceyi MS53 | 6-alkalysalicilic acids, salaceyins A and B | Fatty acid derivatives | Anticancer | – | Singh and Dubey, 2018 |
| Endophytic bacteria | |||||
| Acinetobacter guillouiae | EtOAc extract | – | Anticancer | U87MG glioblastoma and A549 lung carcinoma cells | Sebola et al., 2019 |
| Bacillus subtilis PXJ-5, Bacillus sp. CPC3, Bacillus cereus strain ChST | Camptothecine | Alkaloids | Anticancer | – | Shweta et al., 2013 |
| – | EtOAc extract | – | Cytotoxic | A549 lung cancer cell lines | Swarnalatha and Saha, 2016 |
| Pantoea sp. | EtOAc extract | – | Anticancer | A549 lung carcinoma and UMG87 glioblastoma cell lines | Uche-Okereafor et al., 2019 |