Table 1.

Functional characteristics of circHIPK3 in multiple human cancers.

Cancer types	Expression	Roles	Functional roles	Related genes and protein	References
Lung cancer	Upregulated	Tumor promoter	Viability, proliferation, apoptosis	SphK1, STAT3, CDK4	(43)
	Upregulated	Tumor promoter	Proliferation, migration, autophagy	STAT3	(44)
	N/A	Tumor promoter	Proliferation	IGF1	(45)
	Upregulated	Tumor promoter	Proliferation, migration, invasion, apoptosis	FOXM1	(46)
Gastric cancer	Upregulated	Tumor promoter	Proliferation	COL1A1, COL4A1, CDK6	(47)
	Downregulated	Tumor suppressor	N/A	N/A	(48)
	Upregulated	Tumor promoter	Proliferation, migration	WNT1, TCF4, β-catenin	(49)
Colorectal cancer	Upregulated	Tumor promoter	Proliferation, migration, invasion, apoptosis, metastasis	c-Myb, FAK, IGF1R, EGFR, YY1	(50)
	Upregulated	Tumor promoter	oxaliplatin resistance, autophagy	STAT3, Bcl-2, beclin1	(51)
Bladder cancer	Downregulated	Tumor suppressor	Migration, invasion, angiogenesis, metastasis	HPSE	(52)
Nasopharyngeal carcinoma	Upregulated	Tumor promoter	Proliferation, migration, invasion	ELF3	(53)
Gallbladder cancer	Upregulated	Tumor promoter	Viability, proliferation, apoptosis	ROCK1, CDK6	(54)
Hepatocellular carcinoma	Upregulated	Tumor promoter	Proliferation, migration	AQP3	(55)
Osteosarcoma	Downregulated	Tumor suppressor	Proliferation, migration, invasion	N/A	(56)
Glioma	Upregulated	Tumor promoter	Proliferation, migration, invasion	IGF2BP3	(57)
Epithelial ovarian cancer	Upregulated	Tumor promoter	N/A	N/A	(58)
Prostate cancer	Upregulated	Tumor promoter	Proliferation, invasion	MCL1	(59)
Oral squamous cell carcinoma	Upregulated	Tumor promoter	Proliferation	N/A	(60)
Chronic myeloid leukemia	Upregulated	Tumor promoter	N/A	N/A	(61)