TABLE 2.

Differences in Key Baseline and CPX Variables According to BMI Classification in Aerobic Capacity Subgroups^a

	Low FIT (n=801)			High FIT (n=1265)
Variable	BMI 18.5–24.9 (n=192)	BMI 25.0–29.9 (n=275)	BMI ≥30.0 (n=334)	BMI 18.5–24.9 (n=378)	BMI 25.0–29.9 (n=493)	BMI ≥30.0 (n=394)
Age (y), mean ± SD	60.4±13.6	58.6±12.8	54.8±12.5b	55.3±16.5	56.9±14.0	54.3±13.1c
Male sex (%)	65	78d	70	72e	88	86
BMI, mean ± SD	22.6±1.7f	27.5±1.5f	35.8±5.6f	22.5±1.7f	27.4±1.4f	34.1±4.1f
NYHA class, mean ± SD	2.7±0.80	2.8±0.68	2.7±0.75	2.3±0.71	2.2±0.83	2.2±0.84
HF ischemic etiology, No. (%)	90 (47)	135 (49)	127 (38)g	132 (35)	207 (42)h	118 (30)
LVEF (%), mean ± SD	25.7±10.8	26.2±9.3	26.0±9.7	30.3±10.8	30.7±9.7	29.2±9.8
Prescribed ACE inhibitor, No. (%)	125 (65)	176 (64)	203 (61)	234 (62)	276 (56)i	244 (62)
Prescribed β-blocker, No. (%)	134 (70)	206 (75)	271 (81)j	241 (64)	315 (64)	272 (69)
Peak RER, mean ± SD	1.10±0.15	1.10±0.16	1.10±0.15	1.12±0.14	1.12±0.13	1.11±0.13
Peak $\stackrel{.}{\text{V}}{\text{O}}_2$ (mL O2 · kg−1 · min−1), mean ± SD	10.9±2.3	11.5±2.1k	10.8±2.3	22.3±8.2l	21.1±6.4m	19.5±5.1
VE/VCO2 slope, mean ± SD	43.7±12.3n	38.6±9.7	36.9±10.2	32.5±7.7o	30.9±6.6p	29.5±5.6

^aACE = angiotensin-converting enzyme; BMI = body mass index; CPX = cardiopulmonary exercise testing; FIT = cardiorespiratory fitness (low: <14 ml O₂ · kg⁻¹ · min⁻¹; high: ≥14 mL O₂ · kg⁻¹ · min⁻¹); HF = heart failure; LVEF = left ventricular ejection fraction; NYHA = New York Heart Association; RER = respiratory exchange ratio; VE/VCO₂ = minute ventilation/carbon dioxide production; $\stackrel{.}{\text{V}}{\text{O}}_2$ = oxygen consumption.

^bThe BMI ≥30.0 group significantly less than the BMI 25.0 to 29.9 (P<.001) and BMI 18.5 to 24.9 (P<.001) groups.

^cThe BMI ≥30.0 group significantly less than the BMI 25.0 to 29.9 (P=.02) group.

^dThe BMI 25.0 to 29.9 group significantly greater than the BMI 18.5 to 24.9 (P<.001) and BMI ≥30.0 (P<.001) groups.

^eThe BMI 18.5 to 24.9 group significantly less than the BMI 25.0 to 29.9 (P<.001) and BMI ≥30.0 (P<.001) groups.

^fAll the BMI groups are significantly different in the low and high FIT groups (P<.001).

^gThe BMI ≥30.0 group significantly less than the BMI 25.0 to 29.9 (P<.001) and BMI 18.5 to 24.9 (P=.01) groups.

^hThe BMI 25.0 to 29.9 group significantly greater than the BMI 18.5 to 24.9 (P=.008) and BMI ≥30.0 (P<.001) groups.

ⁱThe BMI 25.0 to 29.9 group significantly less than the BMI 18.5 to 24.9 (P=.009) and BMI ≥30.0 (P=.02) groups.

^jThe BMI ≥30.0 group significantly greater than the BMI 25.0 to 29.9 (P=.02) and BMI 18.5 to 24.9 (P<.001) groups.

^kThe BMI 25.0 to 29.9 group significantly greater than the BMI 18.5 to 24.9 (P=.03) and BMI ≥30.0 (P=.001) groups.

^lThe BMI 18.5 to 24.9 group significantly greater than the BMI 25.0 to 29.9 (P=.02) and BMI ≥30.0 (P<.001) groups.

^mThe BMI 25.0 to 29.9 group significantly greater than the BMI ≥30.0 group (P=.002).

ⁿThe BMI 18.5 to 24.9 group significantly greater than the BMI 25.0 to 29.9 (P<.001) and BMI ≥30 (P<.001) groups.

^oThe BMI 18.5 to 24.9 group significantly greater than the BMI 25.0 to 29.9 (P=.002) and BMI ≥30 (P<.001) groups.

^pThe BMI 25.0 to 29.9 group significantly greater than the BMI ≥30.0 group (P=.004).