Skip to main content
. 2020 May 21;7(3):ENEURO.0395-19.2020. doi: 10.1523/ENEURO.0395-19.2020

Figure 2.

Figure 2.

ErbB4 KO mice are hyperactive in novel environments and sensitive to systemic amphetamine. A, Horizontal locomotor activity of control (Ctrl, black) and ErbB4 KO (KO, blue) mice scored in their home cages for 96 h (n = 8/genotype, p > 0.05). B, Locomotor activity of ErbB4 KO mice (KO, blue) is significantly elevated relative to controls (Ctrl, black) in the novelty open field test (n = 9/genotype, F(2,24) = 36.77, p < 0.0001). C, Locomotor activity of controls (Ctrl, black) and ErbB4 KO mice (KO, blue) following administration (intraperitoneal) of 0–3.5 mg/kg amphetamine. ErbB4 KO mice (0 mg/kg, n = 9; 0.5–3.5 mg/kg, n = 8) show locomotor hypersensitivity to systemic amphetamine administration at different doses as in contrast to Ctrl mice (0 mg/kg, n = 8; 0.5 mg/kg, n = 10; 1.5 and 2.5 mg/kg, n = 8; 3.5 mg/kg, n = 9; F(1,74) = 16.85, p = 0.0001); *p < 0.05, **p < 0.01, ***p < 0.001.