Figure 3.

ErbB4 KO mice exhibit spatial learning and memory deficits. A, ErbB4 KO mice (n = 13) show deficits during the NOR test as compared with control mice (Ctrl, n = 13). ErbB4 KO mice were impaired to differentiate between the novel versus familiar object, assessed by the total time each object was explored during the probe session. B, In contrast to control mice (Ctrl, black, n = 11), ErbB4 KO mice (KO, blue, n = 11) had lower spontaneous alternation in the T-maze. C, Barnes maze (n = 14/genotype) revealed learning deficits in ErbB4 KO mice to locate the target during the training sessions (days 1–4), including higher latency time to find the target (left panel) and more errors (right panel). D, Consistently, the probe session (day 5) indicated that ErbB4 KO mice were impaired to locate the target, as the time spent in the correct zone was reduced (left panel), the number of incorrect nose pokes (errors) were higher (middle panel), and the number of nose pokes in the target and holes +1 and −1 were significantly lower than controls (right panel); *p < 0.05, **p < 0.01.