Figure 6.

ErbB4 KO mice do not show differences in energy balance and body composition. A, ErbB4 KO mice (KO, blue) kept with regular chow and water ad libitum in their home cages did not show differences with control (Ctrl, black) mice in body weight when continuously monitored every 30 d up to 360 d (n = 7/genotype, p > 0.05). The shaded area around ErbB4 KO and Ctrl lines represent the SEM. B, Moreover, an independent cohort of 90-d-old ErbB4 KO and Ctrl mice (n = 13/genotype) with free access to food and water were analyzed during 10 consecutive days for body weight, (C) energy intake, (D) energy expenditure, and (E) body mass composition. In agreement to A, 90-d-old ErbB4 KO and Ctrl mice have similar body weights (p > 0.05; B). Consistently, the energy intake between ErbB4 KO and Ctrl mice (p > 0.05; C) and energy expenditure did not show differences (p > 0.05; D). E, Finally, no differences between fat/lean body mass composition was observed between genotypes (p > 0.05). Data are expressed as the mean ± SEM.