Table 3.
Comparison of PET positive and negative patients with CAA. p-values were obtained using one-way ANOVA (age), chi squared (sex) tests, or Wilcoxon-Mann-Whitney tests (remainder)
| PET positive (n = 5) | PET negative (n = 5) | p | |
| Age, y, mean (SD) | 69.4 (3.1) | 67.8 (2.9) | 0.43 |
| Sex, female, n (%) | 1 (20.0) | 1 (20.0) | 1.00 |
| MMSE, median (IQR) | 29 (29 to 29) | 29 (28 to 30) | 0.83 |
| Aβ38, pg/ml, median (IQR) | 2450 (1350 to 2500) | 1480 (1440 to 1500) | 0.46 |
| Aβ40, pg/ml, median (IQR) | 4140 (2800 to 4370) | 3130 (3040 to 3170) | 0.60 |
| Aβ42, pg/ml, median (IQR) | 92.5 (89.4 to 105) | 134 (131 to 140) | 0.047 |
| sAβPPα, pg/ml, median (IQR) | 81.0 (67.9 to 96.2) | 98.5 (69.4 to 100) | 0.60 |
| sAβPPβ, pg/ml, median (IQR) | 82.8 (79.0 to 104) | 88.7 (66.3 to 94.1) | 0.75 |
| t-tau, pg/ml, median (IQR) | 440 (431 to 458) | 247 (222 to 258) | 0.016 |
| p-tau, pg/ml, median (IQR) | 72.1 (70.8 to 87.8) | 45.8 (42.1 to 49.1) | 0.009 |
| NFL, pg/ml, median (IQR) | 8380 (7260 to 10400) | 2390 (2230 to 2440) | 0.016 |
| sTREM2, pg/ml, median (IQR) | 8500 (7300 to 9780) | 6660 (5420 to 6780) | 0.12 |
| Neurogranin, pg/ml, median (IQR) | 491 (489 to 604) | 349 (334 to 373) | 0.016 |