Table 1.
Baseline demographic characteristics of the Fox Insight cohort and comparator cohorts. Percentages are based on number endorsing divided by specified sample in parenthesis. Blank cells indicate data were not collected in a given cohort
| Item | Fox Insight | Early Fox Insight | PPMI | PDBP | iPDLC | Sig. diff | Post-hoc effect sizes |
| Age (mean (SD)) | 65.77 (9.49) | 64.31 (10) | 61.62 (9.68) | 65.2 (9.09) | 66.67 (10.62) | * | Early FI vs. PPMI: 0.27 |
| Range (years) | (18.1–98.8) | (25.2–93.4) | (33.5–84.88) | (34.75–87.5) | (26–89) | ||
| Sex | * | FI vs. PDBP: 0.043 | |||||
| Male | 54.44% (6889/12654) | 53.07% (2161/4072) | 65.64% (277/422) | 64.29% (450/700) | 60.43% (307/508) | Early FI vs. PPMI: 0.072 | |
| Female | 45.56% (5765/12654) | 46.93% (1911/4072) | 34.36% (145/422) | 35.71% (250/700) | 39.57% (201/508) | ||
| BMI (kg/m2) | 26.79 (6.54) | 27.21 (5.95) | 27.15 (4.63) | ||||
| Range | (8.87–231.93) | (8.87–165.31) | (16.66–43.76) | ||||
| Race | * | FI vs. iPDLC: 0.034 | |||||
| White | 96.85% (12183/12579) | 97.11% (3933/4050) | 92.42% (390/422) | 96.85% (677/699) | 100% (508/508) | Early FI vs. PPMI: 0.075 | |
| NonWhite | 3.15% (396/12579) | 2.89% (117/4050) | 7.58% (32/422) | 3.15% (22/699) | 0% (0/508) | ||
| Ethnicity | |||||||
| Hispanic | 3.81% (469/12317) | 3.28% (131/3997) | 2.13% (9/422) | 1.92% (13/678) | 2.5% (1/40) | ||
| NonHispanic | 96.19% (11848/12317) | 96.72% (3866/3997) | 97.87% (413/422) | 98.08% (665/678) | 97.5% (39/40) | ||
| Education | * | FI vs. iPDLC: 0.102 | |||||
| Less than 9 years | 0.98% (123/12606) | 0.86% (35/4054) | 1.66% (7/422) | 0.29% (2/700) | 2.82% (14/497) | FI vs. PDBP: 0.053 | |
| 9–12 years | 8.83% (1113/12606) | 8.53% (346/4054) | 16.11% (68/422) | 15.71% (110/700) | 19.92% (99/497) | Early FI vs. PPMI: 0.078 | |
| 13–16 years | 55.39% (6982/12606) | 56.83% (2304/4054) | 49.76% (210/422) | 52.86% (370/700) | 32.39% (161/497) | ||
| More than 16 years | 34.81% (4388/12606) | 33.77% (1369/4054) | 32.46% (137/422) | 31.14% (218/700) | 44.87% (223/497) | ||
| PD Duration (mean years) | 5.21 (5.21) | 0.94 (0.6) | 0.55 (0.54) | 6.42 (5.48) | 4.69 (4.91) | * | FI vs. PDBP: 0.232 |
| Range | (0–62.5) | (0–2) | (0.03–2.99) | (0–38.33) | (0–35) | Early FI vs. PPMI: 0.656 | |
| 0–2 years | 30.73% (3888/12654) | 95.50% (3888/4072) | 96.68% (408/422) | 23.29% (163/700) | 31.89% (162/508) | * | FI vs. PDBP: 0.035 |
| 2–5 years | 30.29% (3833/12654) | 4.52% (184/4072) | 3.32% (14/422) | 25.43% (178/700) | 27.95% (142/508) | ||
| 5–10 years | 24.02% (3039/12654) | 29% (203/700) | 25.79% (131/508) | ||||
| 10+ years | 14.97% (1894/12654) | 22.29% (156/700) | 14.37% (73/508) | * | FI vs. PDBP: 0.044 | ||
| Family History (1st Degree) | 22.32% (2371/10621) | 22.28% (722/3241) | 13.06% (55/421) | 17.82% (103/578) | 16.67% (81/486) | * | Early FI vs. PPMI: 0.07 |