Table 3.

Results of the multivariate generalized estimating equation model

Nuclei Clinical Metric	Change in Nuclei Volumes (Beta Coefficient)	95% Confidence Interval
		lower	upper	p value
Substantia Nigra
Bradykinesia-Rigidity Subscore	–6.15	–9.81	–2.48	0.001
Tremor Subscale	0.72	–7.33	8.76	0.86
Duration	–24.87	–35.74	–14.00	<0.0001
Age	–4.16	–6.73	–1.58	0.0002
Subthalamic Nucleus
Bradykinesia-Rigidity Subscore	–0.64	–2.69	1.40	0.54
Tremor Subscale	2.94	–1.18	7.07	0.16
Duration	3.42	–2.41	9.26	0.25
Age	1.70	–0.13	3.45	0.07
Red Nucleus
Bradykinesia-Rigidity Subscore	–0.85	–2.96	1.27	0.43
Tremor Subscale	–0.04	–4.00	3.92	0.98
Duration	0.16	–6.65	6.97	0.96
Age	0.79	–1.49	3.07	0.50