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Domain structure of the human alpha-synuclein (α-Syn) protein. α-Syn comprises three basic domains: an N-terminal amphipathic region, a central non-β-amyloid component (NAC) domain, and a C-terminal acidic domain. Seven membrane-interacting amino acid motifs are also present in the first half of the protein. The region preceding the NAC domain concentrates all pathogenic α-Syn mutations identified so far. Numbers on the upper part of the structure refer to amino acid positions.
