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. 2020 Apr 28;39:101006. doi: 10.1016/j.molmet.2020.101006

Figure 1.

Figure 1

DDR1 deficient mice have reduced body weight and adiposity after feeding HFD for 12 weeks. (A-B) Ddr1+/+; Ldlr−/- (Ddr1+/+; n = 13) and Ddr1−/−; Ldlr−/- (Ddr1−/−; n = 13) mice (A) were fed high-fat diet (HFD) for 12 weeks and weighed weekly (B). (C) Food consumption was recorded. (D) Tissue weights were recorded after HFD. (E-F) Epididymal (E) and interscapular (F) adipose tissue from Ddr1+/+ and Ddr1−/− mice fed HFD. (G-I) Ddr1+/+ (Ddr1+/+(BL6); n = 11) and Ddr1−/− (Ddr1−/−(BL6); n = 12) mice (G) on C57BL6 background were fed high-fat diet (HFD) for 12 weeks and body weight (H) and food consumption (I) were recorded. (J) Tissue weights were recorded. (K-L) Epididymal (K) and interscapular (L) adipose tissue from Ddr1+/+(BL6) and Ddr1−/−(BL6) mice fed HFD. Statistical analysis was performed by 2-way ANOVA with Bonferroni post-hoc test (B, D, H, and J), and student's t-test (C and I). The values are mean ± SEM. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.