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. 2020 Apr 28;39:101006. doi: 10.1016/j.molmet.2020.101006

Figure 4.

Figure 4

DDR1 deficient mice have reduced adipocyte size after 12 weeks on HFD. (A) Epididymal (eFat) and subcutaneous (sFat) tissues were isolated from Ddr1+/+ and Ddr1−/− mice and stained with H&E to visualize adipocyte size (scale bars = 100 μm). (B–C) Adipocyte size distribution was measured from H&E stains of eFat before (B; 6wk) and after (C; 12wk) on HFD (n = 3). (D) Mean adipocyte size was determined in eFat before and after HFD-feeding (n = 3). (E-F) Adipocyte size distribution in sFat before (E; 6wk) and after (F; 12wk) HFD-feeding. (G) Mean adipocyte size in sFat before and after HFD (n = 3). Statistical analysis was performed by 2-way ANOVA with Bonferroni post-hoc test (B, C, E, and F) and by 1-way ANOVA with Bonferroni post-hoc test (D and G). The values are mean ± SEM. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, comparing Ddr1+/+ to Ddr1−/−. ††p < 0.01, comparing HFD-fed to pre-HFD-feeding.