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Generation of the GHSR-A203E and GHSR-A203E-null mouse models. (A) Schematic diagram of the derivation of the GHSR-A203E and GHSR-A203E-null mouse models by homologous recombination. (B) Hypothalamic expression of food intake- and body weight-related transcripts in 66-week-old mice (n = 7–9 per group). (C) Pituitary expression of GH secretion-related transcripts in 14-week-old males (n = 3 per group). Data were analyzed by unpaired Student's t-test. #P = 0.051.
