Metabolic phenotype of wild-type and GHSR-A203E littermates. (A–B) Body weight, (C–D) % weight gain, (E–F) food intake, (G–H) food intake/body weight, and (I–J) cumulative feed efficiency in male (A, C, E, G, and I) and female (B, D, F, H, and J) wild-type (n = 7–9) and GHSR-A203E (n = 10–12) littermates. (K–L) Nose-anus body lengths in 26-week-old male (K) (n = 8–10) and 25-week-old female (L) (n = 9–12) mice. (M) Femur length in 26-week-old male (n = 8–10) mice. Data were analyzed by (A–J) repeated measures 2-way ANOVA followed by a Tukey post hoc analysis or (K–M) Student's unpaired t-test. ∗P < 0.05, ∗∗∗P < 0.001, ∗∗∗∗P < 0.0001, #0.05 ≤ P < 0.1, and n.s. = non-significant.