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. 2020 Apr 24;39:101004. doi: 10.1016/j.molmet.2020.101004

Figure 8.

Figure 8

Effects of a 7-d severe (60%) caloric restriction protocol. (A) Body weights, (B) % fat mass, (C) % lean mass (n = 9–20), (D) plasma GH levels (n = 7–10), (E) plasma ghrelin (n = 7–13), (F) blood glucose (n = 9–20), and (G) % survival (9/9 wild-type mice and 17/20 GHSR-A203E mice) over the 7-d course of daily access to 40% of usual daily calories. (A–F) Data were analyzed by 2-way ANOVA followed by Tukey post hoc analyses. (G) Survival curves were calculated by the Kaplan–Meier method, with comparisons determined using the Mantel–Cox log-rank test. ∗P < 0.05, ∗∗∗∗P < 0.0001, and n.s. = non-significant.