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. 2020 May 22;11(5):390. doi: 10.1038/s41419-020-2544-7

Fig. 5. Administration of dapagliflozin ameliorates glomerular and tubular damage of diabetic kidney.

Fig. 5

a, b Data of food intake (a) and water intake (b) at 12 weeks of treatment. c Time course data of blood glucose. d–g Data of urinary glucose (d), kidney/body weight ratio (e), urinary albumin (f), urinary NGAL (g) at 12 weeks of treatment. Data are shown as mean ± SD. *p < 0.05 compared with control; **p < 0.01 compared with control; †p < 0.05 compared to diabetes + vehicle. ††p < 0.01 compared with diabetes + vehicle. h Representative images of mice kidney sections from the groups indicated with H&E, PAS, Masson, Sirius red staining, and immunostaining for F4/80. Scale bar = 50 μm. i–m Glomerular tuft area (i), fractional mesangial area (FMA) % (j), total collagen (k), fibrotic area (l), and F4/80 lebelled cells per field (m) at 12 weeks of treatment. Data are shown as mean ± SD. *p < 0.05 compared with control; **p < 0.01 compared with control; †p < 0.05 compared with diabetes + vehicle; ††p < 0.01 compared with diabetes + vehicle.