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. 2020 May 22;11(5):390. doi: 10.1038/s41419-020-2544-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Representative images of mice kidney sections from the groups with BODIPY staining. Scale bars, 25 μm. b Quantification of BODIPY positive area in kidney samples from the groups indicated. **p < 0.01 compared with control; ^††p < 0.01 compared with diabetes + vehicle. c Triacylglycerol (TG) contents in mouse kidney tissue from the group as indicated. Data are shown as mean ± SD. *p < 0.05 compared with control; **p < 0.01 compared with control; ^†p < 0.05 compared with diabetes + vehicle. d–f Relative mRNA levels of Pparα (d), Cpt1α (e), and Acadl (f) in samples from the groups indicated. *p < 0.05 compared with control; **p < 0.01 compared with control; ^†p < 0.05 compared with diabetes + vehicle; ^††p < 0.01 compared with diabetes + vehicle. g–i Relative mRNA levels of Hk2 (g), Ldh (h), and Pdk1 (i) in samples from the groups indicated. *p < 0.05 compared with control; **p < 0.01 compared with control; ^†p < 0.05 compared with diabetes + vehicle; ^††p < 0.01 compared with diabetes + vehicle. j Quantification of lactate in kidney tissue samples from the groups indicated. *p < 0.05 compared with control; **p < 0.01 compared with control; ^††p < 0.01 compared with diabetes + vehicle. k Western blot analysis of HIF-1α and PHD2 protein and relative protein expression level in the groups as indicated. **p < 0.01 compared with control; ^†p < 0.05 compared with diabetes + vehicle; ^††p < 0.01 compared with diabetes + vehicle.