REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
PAX7 mouse monoclonal antibody	DSHB	#MAB1675; RRID:AB_528428
RIPK3 rabbit polyclonal antibody	Abcam	#ab56164; RRID:AB_2178667
Cleaved Caspase-3 (Asp175) rabbit polyclonal antibody	Cell Signaling Technology	#966; RRID:AB_23411881
Phospho-MLKL (Ser345) rabbit monoclonal antibody	Cell Signaling Technology	#62233; RRID:AB_2734703
PAX7 mouse monoclonal antibody (Human)	Santa Cruz	#sc-81648; RRID:AB_2159836
Phospho-MLKL(Ser358) rabbit monoclonal antibody (Human)	Cell Signaling Technology	#91689; RRID:AB_2732034
SUMO1 rabbit monoclonal antibody	Abcam	#ab32058; RRID:AB_778173
SENP5 rabbit polyclonal antibody	Sigma Aldrich	#SAB1300165; RRID:AB_10608890
CHD4 (Mi-2 beta) rabbit polyclonal antibody	Active Motif	#39289; RRID:AB_261493
CHD4 (D8B12) rabbit monoclonal antibody	Cell Signaling Technology	#11912; RRID:AB_2751014
RIPK3 (G4G2A) rabbit monoclonal antibody	Cell Signaling Technology	#95702; RRID:AB_2721823
GAPDH (14C10) rabbit monoclonal antibody	Cell Signaling Technology	#2118; RRID:AB_561053
HDAC1 (10E2) Mouse monoclonal antibody	Cell Signaling Technology	#5356; RRID:AB_10612242
Pol I/II/III RPB8 (B8-1) Mouse monoclonal antibody	Santa Cruz	#sc-21752; RRID:AB_675858
Anti-Rabbit IgG	Diagenode	# C15410206; RRID:AB_2722554
Anti-Mouse IgG	Diagenode	# C15400001-100; RRID: AB_2722553
Plasmids
pMD2.G plasmid	pMD2.G plasmid was deposited by Didier Trono’s lab.	RRID:Addgene_12259
psPAX2 plasmid	psPAX2 plasmid was deposited by Didier Trono’s lab.	RRID:Addgene # 12260
Scrambled shrna: CCTAAGGTTAAGTCGCCCTCG CTCGAGCGAGGGCGACTTAACCTTAGG	Sigma Aldrich	N/A
Chromatin modifier library shRNAs (Table S2)	Sigma Aldrich	N/A
Ripk3V5 plasmid	Sigma Aldrich	N/A
Chemicals, Peptides, and Recombinant Proteins
Tamoxifen	Sigma Aldrich	Cat# T5648
Dispase	BD	Cat# 354235
Collagenase, Type 2	Worthington Biochemicals	Cat# CLS-2
Percoll	Sigma Aldrich	Cat# P1644
Matrigel Matrix	BD	Cat# 356234
Trizol reagent	Invitrogen	Cat# 15596026
Critical Commercial Assays
Click-iT EdU Kit	Invitrogen	Cat# C10337
SuperScript II Reverse Transcriptase Kit	Invitrogen	Cat# 18091050
DNeasy Blood & Tissue Kit	QIAGEN	Cat# 69504
Nextera DNA Sample Preparation Kit	Illumina	Cat#FC-121-1030
NextSeq500 platform using V2 chemistry	Illumina	Cat#FC-404-2004
Deposited Data
RNaseq data (Figure S2; Table S1)	This paper	GEO: GSE134131
ATACseq and RNaseq data (Figure 3; Table S2)	This paper	GEO: GSE117092; GEO: GSE134132
RNaseq data (Figure 4; Table S4)	This paper	GEO: GSE117008
Proteomics data (Figure 4; Table S4)	This paper	PRIDE: PXD010370
Experimental Models: Cell Lines
HEK293FT	ATCC	Cat# PTA5077
Experimental Models: Organisms/Strains
Chd4loxP/loxP mice	Dr. Pablo Gómez-del Arco	Stock No: 008462
Ripk3loxP/loxP mice	Dr. Boris Strillic	N/A
MLKL knockout	Dr. Boris Strillic	N/A
Casp8loxP/loxP mice	Dr. Stephen Hedrick	N/A
Rosa26eYFP mice	Jackson Laboratory	Stock No: 006148
mdx mice	Jackson Laboratory	Stock No: 001801
Pax7::ZsGreen mice	Dr. Michael Kyba	Stock No: 029549
Pax7CE mice	Dr. Chenming Fan	Stock No: 012476
Software and Algorithms
R language (v3.4.1)	NA	www.r-project.org
GraphPad Prism 7	GraphPad Software	N/A
STAR(v2.5.2b)	N/A	https://bioconda.github.io/
Picard (v1.119)	N/A	https://bioconda.github.io/
Gencode (version vM11)	N/A	https://www.gencodegenes.org/
Oligonucleotides
Oligonucleotides used for genotyping and mRNA expression analysis are provided in Table S5		N/A