Table 1.
The relationship between AKNA expression level and clinicopathological factors in 354 GC cases from the TCGA database.
| Characteristics | N | Expression of AKNA | χ2 | P | |
|---|---|---|---|---|---|
| Low | High | ||||
| Gender | 354 | 101 | 253 | 0.108 | 0.742 |
| Male | 229 | 64 (27.9%) | 165 | ||
| Female | 125 | 37 (29.6%) | 88 | ||
| Age(years) | 351 | 101 | 250 | 3.41 | 0.065 |
| ≤65 | 150 | 37 (24.7%) | 113 | ||
| >65 | 201 | 64 (31.8%) | 137 | ||
| Tumor sites | 340 | 96 | 244 | 13.256 | 0.004 |
| Gastroesophageal junction | 39 | 16 (41.0%) | 23 | ||
| Cardiac | 45 | 19 (42.2%) | 26 | ||
| Fundus/body | 124 | 23 (18.5%) | 101 | ||
| Antrum | 132 | 38 (28.8%) | 94 | ||
| WHO's histological types | 103 | 24 | 79 | 3.005 | 0.391 |
| Tubular Ade. | |||||
| Moderately Diff. | 5 | 2 (40.0%) | 3 | ||
| Poorly Diff. | 68 | 18 (26.5%) | 50 | ||
| Mucinous Ade. | 11 | 1 (9.1%) | 10 | ||
| Signet ring cell car. | 19 | 3 (15.8%) | 16 | ||
| Lauren's typesa | 233 | 65 | 168 | 1.668 | 0.196 |
| Intestinal type | 161 | 49 (30.4%) | 112 | ||
| Diffuse type | 72 | 16 (22.2%) | 56 | ||
| Depth of invasion | 354 | 101 | 253 | 2.339 | 0.505 |
| T1 | 18 | 7 (38.9%) | 11 | ||
| T2 | 62 | 20 (32.3%) | 42 | ||
| T3 | 12 | 2 (16.7%) | 10 | ||
| T4 | 262 | 72 (27.5%) | 190 | ||
| Ln metastasis | 318 | 83 | 235 | 2.375 | 0.498 |
| N0 | 89 | 25 (28.1%) | 64 | ||
| N1 | 66 | 19 (28.8%) | 47 | ||
| N2 | 73 | 14 (19.2%) | 59 | ||
| N3 | 90 | 25 (27.8%) | 65 | ||
| Distant metastasis | 338 | 97 | 241 | 9.337 | 0.002 |
| M0 | 315 | 84 (26.7%) | 231 | ||
| M1 | 23 | 13 (56.5%) | 10 | ||
| TNM staging | 306 | 82 | 224 | 15.012 | 0.002 |
| I | 42 | 15 (35.7%) | 27 | ||
| II | 57 | 15 (26.3%) | 42 | ||
| III | 184 | 39 (21.2) | 145 | ||
| IV | 23 | 13 (56.5%) | 10 | ||
Ade.: adenocarcinoma; Diff.: differentiated; Car.: carcinoma; Ln.: lymph node.aLauren's types data of 121 GC cases is unavailable.