Table 2.
Logistic regression analysis of radiation-induced hypothyroidism in 170 patients with NPC.
| Variables (reference group) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | |
| Age | 0.98 (0.95-1.01) | 0.1354 | ||
| Sex male (versus female) | 0.46 (0.24-0.89) | 0.0206∗ | 0.73 (0.33-1.61) | 0.4342 |
| BMI underweight (versus normal) | 0.4 (0.08-2.08) | 0.2396 | ||
| BMI overweight (versus normal) | 1.16 (0.58-2.3) | 0.2438 | ||
| T-stage T2-3 (versus T0-1) | 0.73 (0.34-1.57) | 0.4248 | ||
| N-stage N2-3 (versus N0-1) | 2.01 (1.05-3.85) | 0.0344∗ | 1.34 (0.63-2.85) | 0.4527 |
| M-stage M1 (versus M0) | 2.54 (0.61-10.49) | 0.1993 | ||
| Clinical stage IV (versus I-III) | 0.65 (0.35-1.19) | 0.1576 | ||
| Neoadjuvant chemotherapy (yes (versus no)) | 1.7 (0.41-7.04) | 0.4635 | ||
| TPO-Ab | 1.014 (1.003-1.026) | 0.0144∗ | 1.01 (1.002-1.03) | 0.025∗ |
| TG-Ab | 1.004 (1.001-1.006) | 0.0024∗∗ | 1.004 (1.001-1.01) | 0.0112∗ |
| TG | 1.04 (1.01-1.07) | 0.0105∗ | 1.06 (1.02-1.1) | 0.0009∗∗∗ |
| CD19+ | 1.01 (0.94-1.09) | 0.7506 | ||
| CD3+ | 0.99 (0.97-1.02) | 0.4777 | ||
| CD4+ | 1.00 (0.97-1.03) | 0.9681 | ||
| CD8+ | 0.98 (0.95-1.02) | 0.3422 | ||
| CD4+/CD8+ | 1.16 (0.82-1.63) | 0.4024 | ||
| CD38+ | 0.99 (0.92-1.06) | 0.7707 | ||
| CD45RA- | 1.02 (0.97-1.06) | 0.5055 | ||
| CD45RA+ | 1.00 (0.95-1.06) | 0.9631 | ||
| CD45RO+ | 1.03 (0.98-1.07) | 0.2625 | ||
| CD45RA+/CD45RO+ | 1.05 (0.91-1.21) | 0.5254 | ||
| CD56+ | 1.01 (0.98-1.04) | 0.5395 | ||
| Neutrophils/lymphocytes | 1.02 (0.96-1.08) | 0.4844 | ||
| EBV DNA | 1 (1-1) | 0.3799 | ||
| Cholinesterase | 1 (1-1) | 0.1324 | ||
| Fb | 1.88 (1.21-2.9) | 0.0046∗∗ | 1.93 (1.17-3.17) | 0.0098∗∗ |
Note: ∗P < 0.05; ∗∗P < 0.01; and ∗∗∗P < 0.001.