Table 1.
Antioxidant activity of N1-(4-arylidene)-1H-benzo[d]imidazole-2-carbohydrazides 3–15.
| ||||
|---|---|---|---|---|
| Compound | Aryl | DPPH a µmolTE/g |
FRAP a µmolTE/g |
ORAC a µmolTE/g |
| Ferulic acid | 4379.0 ± 9.8 | 6872.6 ± 9.7 | 15,906.4 ± 14.2 | |
| 3 | 2-OH-phenyl | <23.2 b | 48.0 ± 2.6 | - |
| 4 | 3-OH-phenyl | <13.0 b | 1023.3 ± 9.4 | 21,808.0 ± 99.1 |
| 5 | 4-OH-phenyl | 29.6 ± 0.1 | 1040.1 ± 11.2 | 30,911.3± 36.4 |
| 6 | 2,4-(OH)2-phenyl | 200.6 ± 1.5 | 286.7 ± 10.3 | 9296.8 ± 72.3 |
| 7 | 2,5-(OH)2-phenyl | 9387.9 ± 13.8 | 5330.6 ± 29.6 | 17,856.9 ± 35.1 |
| 8 | 2,3,4-(OH)3-phenyl | 10,945.2 ± 38.5 | 10,064.6 ± 24.6 | 4221.5 ± 10.5 |
| 9 | 2,4,6-(OH)3-phenyl | 192.6 ± 3.5 | 4071.7 ± 10.0 | 4098.6 ± 39.1 |
| 10 | 2-OH-4-OMe-phenyl | 201.2 ± 4.9 | 231.9 ± 5.5 | - |
| 11 | 2-OH-3-OEt-phenyl | 38.1 ± 1.6 | 104.5 ± 2.1 | - |
| 12 | 3-OH-4-OMe-phenyl | 171.5 ± 6.1 | 3418.8 ± 15.2 | 17,170.7 ± 18.4 |
| 13 | 2-OH-4-N(Et)2-phenyl | 1065.0 ± 5.9 | 3525.4 ± 13.4 | 754.4 ± 19.0 |
| 14 | 2-OH-5-Cl-phenyl | << 13.29 b | 54.8 ± 1.3 | - |
| 15 | 2-OH-5-Br-phenyl | 28.8 ± 1.2 | 81.7 ±2.7 | - |
a Each value was obtained from three experiments (mean ± SE);—not tested. b LOQ limit of quantification;—not tested.