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. 2020 Apr 5;13(4):62. doi: 10.3390/ph13040062

Table 2.

Comparison of IC50 values in inhibiting frog sciatic nerve fast-conducting CAPs, TTX-sensitive or -resistant Na+ channels among NSAIDs.

NSAIDs Frog CAP
IC50 (mM)		 TTX-Sensitive
Na+ Channel
Current IC50 (mM)		 TTX-Resistant
Na+ Channel
Current IC50 (mM)		 References
Acetic Acid-Based Diclofenac 0.94 0.00851, 0.014 ca. 20% reduction
(0.3 mM)		 [21,108,110,115]
Aceclofenac 0.47 [21]
Indomethacin 38% reduction (1 mM) [21]
Acemetacin 38% reduction (0.5 mM) [21]
Etodolac 15% reduction (1 mM) [21]
Sulindac n.d.
(no effect, 1 mM)		 [21]
Felbinac n.d.
(no effect, 1 mM)		 [21]
Fenamic Acid-Based Tolfenamic acid 0.29 ca. 70% reduction (0.1 mM) ca. 30% reduction (0.1 mM) [21,116]
Meclofenamic acid 0.19 [21]
Mefenamic acid 16% reduction (0.2 mM) [21]
Flufenamic acid 0.22 ca. 60% reduction
(0.1 mM)		 ca. 30% reduction
(0.1 mM)		 [21,116]
0.189 [114]
Salicylic
Acid-Based		 Aspirin n.d.
(no effect, 1 mM)		 [21]
Propionic
Acid-Based		 Ketoprofen n.d.
(no effect, 1 mM)		 [21]
Naproxen n.d.
(no effect, 1 mM)		 [21]
Ibuprofen n.d.
(no effect, 1 mM)		 [21]
Loxoprofen n.d.
(no effect, 1 mM)		 [21]
Flurbiprofen n.d.
(no effect, 1 mM)		 [21]
Enolic
Acid-Based		 Meloxicam n.d.
(no effect, 0.5 mM)		 [21]
Piroxicam n.d.
(no effect, 1 mM)		 [21]

Here, when IC50 values are not available, it is partly shown for comparison how the CAPs and channels are affected by drugs, where % value indicates the extent of the reduction at the concentration shown in parentheses; n.d.: not determined.