Table 2.

Comparison of IC₅₀ values in inhibiting frog sciatic nerve fast-conducting CAPs, TTX-sensitive or -resistant Na⁺ channels among NSAIDs.

NSAIDs		Frog CAP IC50 (mM)	TTX-Sensitive Na+ Channel Current IC50 (mM)	TTX-Resistant Na+ Channel Current IC50 (mM)	References
Acetic Acid-Based	Diclofenac	0.94	0.00851, 0.014	ca. 20% reduction (0.3 mM)	[21,108,110,115]
	Aceclofenac	0.47			[21]
	Indomethacin	38% reduction (1 mM)			[21]
	Acemetacin	38% reduction (0.5 mM)			[21]
	Etodolac	15% reduction (1 mM)			[21]
	Sulindac	n.d. (no effect, 1 mM)			[21]
	Felbinac	n.d. (no effect, 1 mM)			[21]
Fenamic Acid-Based	Tolfenamic acid	0.29	ca. 70% reduction (0.1 mM)	ca. 30% reduction (0.1 mM)	[21,116]
	Meclofenamic acid	0.19			[21]
	Mefenamic acid	16% reduction (0.2 mM)			[21]
	Flufenamic acid	0.22	ca. 60% reduction (0.1 mM)	ca. 30% reduction (0.1 mM)	[21,116]
			0.189		[114]
Salicylic Acid-Based	Aspirin	n.d. (no effect, 1 mM)			[21]
Propionic Acid-Based	Ketoprofen	n.d. (no effect, 1 mM)			[21]
	Naproxen	n.d. (no effect, 1 mM)			[21]
	Ibuprofen	n.d. (no effect, 1 mM)			[21]
	Loxoprofen	n.d. (no effect, 1 mM)			[21]
	Flurbiprofen	n.d. (no effect, 1 mM)			[21]
Enolic Acid-Based	Meloxicam	n.d. (no effect, 0.5 mM)			[21]
	Piroxicam	n.d. (no effect, 1 mM)			[21]

Here, when IC₅₀ values are not available, it is partly shown for comparison how the CAPs and channels are affected by drugs, where % value indicates the extent of the reduction at the concentration shown in parentheses; n.d.: not determined.