Figure 5.

(A) Influence of oleacein on STAT3 cellular level by oxLDL-induced macrophages was analysed by ELISA test. The experiment was performed on cells from different donors (n = 15). Statistical significance * p < 0.05, ** p < 0.001 compared oxLDL-induced macrophages. (B) Phosphorylation of STAT3 (P-STAT3/STAT3), JAK1 (P-JAK1/JAK) and JAK2 (P-JAK2/JAK2) was analysed by Western Blot and based on total protein. The results were quantified by densitometry. Representative images from one of tree experiments are shown. β-actin was used as an internal control. Vehicle: statistical significance ** p < 0.001 compared to the oxLDL-induced macrophages. As an inhibitor of JAK/STAT3 pathway. AZD1480, was used. Statistical significance ** p < 0.001 compared to factors without AZD1480.