Table 6.
Significant score changes in the performance of ε4 carriers and non-ε4 carriers of the Long-Lasting Memories, Active Control, and Physical Training Control groups.
| Neuropsychological tests | Pooled mean ranks: negativea | Pooled mean ranks: positiveb | Averaged median before training | Averaged median after training | Test results | ||||||||
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Wilcoxon signed-rank test | P value | |||||||
| LLMc ε4 carriers |
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Trail Bd | 7.03 | 6.87 | 234.797 | 185.516 | –2.2 | .03 | ||||||
| LLM non-ε4 carriers |
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MMSEe | 14.30 | 20.36 | 27.000 | 28.000 | –2.0 | .047 | ||||||
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MoCAf | 20.24 | 22.85 | 22.915 | 24.000 | –2.2 | .04 | ||||||
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RAVLT1g | 17.33 | 26.15 | 4.523 | 5.463 | –3.0 | .049 | ||||||
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RAVLT totalh | 18.95 | 26.06 | 37.699 | 43.220 | –3.0 | .04 | ||||||
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CVLT1i | 14.47 | 21.42 | 4.751 | 5.566 | –2.6 | .03 | ||||||
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CVLT totalj | 18.88 | 22.97 | 41.605 | 46.994 | –3.4 | .002 | ||||||
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CVLTDk | 14.49 | 22.83 | 8.471 | 9.598 | –2.7 | .02 | ||||||
| Active non-ε4 carriers |
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MMSE | 19.58 | 21.34 | 26.948 | 28.000 | –3.8 | <.001 | ||||||
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MoCA | 17.28 | 27.77 | 22.997 | 24.726 | –2.4 | .04 | ||||||
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RAVLT total | 19.28 | 28.41 | 38.771 | 45.806 | –3.6 | .01 | ||||||
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CVLT1 | 14.54 | 26.21 | 4.507 | 6.832 | –4.2 | <.001 | ||||||
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CVLT total | 12.45 | 26.75 | 39.180 | 48.408 | –4.5 | <.001 | ||||||
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CVLTD | 19.06 | 25.64 | 8.312 | 10.002 | –3.5 | .002 | ||||||
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Digit span backward | 17.41 | 22.16 | 4.000 | 4.362 | –2.3 | .046 | ||||||
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FUCASl | 17.66 | 23.69 | 43.798 | 44.271 | –3.2 | .004 | ||||||
| PTCm ε4 carriers |
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Digit span backward | 2.50 | 3.75 | 4.000 | 5.000 | –2.1 | .03 | ||||||
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GDSn | 3.50 | 0 | 2.000 | 0 | –2.2 | .03 | ||||||
| PTC non-ε4 carriers |
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RAVLT total | 9.37 | 13.62 | 37.509 | 44.118 | –2.6 | .03 | ||||||
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CVLT total | 9.32 | 13.02 | 41.230 | 47.803 | –2.4 | .04 | ||||||
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CVLTD | 9.41 | 13.16 | 7.871 | 10.822 | –3.0 | .03 | ||||||
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Digit span forward | 9.02 | 10.96 | 4.405 | 5.000 | –2.5 | .01 | ||||||
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Digit span backward | 6.52 | 9.96 | 4.000 | 4.000 | –2.2 | .03 | ||||||
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FUCAS | 8.54 | 14.55 | 43.537 | 44.505 | –2.3 | .05 | ||||||
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GDS | 10.68 | 5.28 | 2.000 | 0 | –2.8 | .006 | ||||||
aNegative mean rank: test score post < test score pre.
bPositive mean rank: test score post > test score pre.
cLLM: Long-Lasting Memories.
dTrail B: Trail Making Test, Part B.
eMMSE: Mini-Mental State Examination.
fMoCA: Montreal Cognitive Assessment.
gRAVLT1: Rey Auditory Verbal Learning Test: immediate recall.
hRAVLT total: Rey Auditory Verbal Learning Test: sum up of 5 recall attempts.
iCVLT1: California Verbal Learning Test: immediate recall.
jCVLT total: California Verbal Learning Test: sum up of 5 recall attempts.
kCVLTD: California Verbal Learning Test: delayed recall.
lFUCAS: Functional and Cognitive Assessment Test.
mPTC: Physical Training Control.
nGDS: Geriatric Depression Scale.