Table 2.
Prevalence of symptom domains and poor HRQOL among overall HSCT survivors, conventional therapy survivors, and noncancer controls
| Symptoms and HRQOL | HSCT survivors | Conventional therapy survivors | Noncancer controls | HSCT survivors vs conventional therapy survivors | HSCT survivors vs noncancer controls |
|---|---|---|---|---|---|
| n (%) | n (%) | n (%) | OR (95% CI)* | OR (95% CI)* | |
| Symptom prevalence | |||||
| Sensation abnormalities | 44 (39.3) | 365 (33.0) | 45 (18.6) | 1.5 (1.0-2.3) | 4.7 (2.6-8.4) |
| Motor/movement problems | 14 (12.5) | 149 (13.5) | 8 (3.3) | 1.0 (0.5-1.8) | 4.3 (1.6-11.0) |
| Cardiac symptoms | 15 (13.4) | 150 (13.6) | 16 (6.6) | 1.0 (0.6-1.8) | 2.5 (1.1-5.6) |
| Pulmonary symptoms | 15 (13.4) | 152 (13.7) | 9 (3.7) | 1.0 (0.6-1.8) | 4.6 (1.8-11.8) |
| Pain | 72 (64.3) | 819 (74.1) | 159 (65.7) | 0.7 (0.4-1.0) | 1.4 (0.8-2.3) |
| Fatigue | 15 (13.4) | 195 (17.6) | 18 (7.4) | 0.7 (0.4-1.4) | 3.1 (1.4-7.0) |
| Nausea | 15 (13.4) | 152 (13.7) | 27 (11.2) | 1.0 (0.6-1.8) | 1.3 (0.7-2.7) |
| Memory problems | 32 (28.6) | 276 (25.0) | 19 (7.9) | 1.2 (0.8-1.9) | 4.8 (2.5-9.2) |
| Anxiety | 33 (29.5) | 386 (34.9) | 44 (18.2) | 0.8 (0.5-1.3) | 2.1 (1.2-3.6) |
| Depression | 27 (24.1) | 341 (30.8) | 45 (18.6) | 0.8 (0.5-1.2) | 1.7 (0.9-2.9) |
| Multiple (≥2) symptoms | 65 (63.7) | 648 (61.9) | 88 (36.8) | 1.1 (0.7-1.7) | 3.0 (1.9-4.9) |
| Poor HRQOL | |||||
| PCS ≤40 | 19 (17.0) | 156 (14.1) | 13 (5.4) | 1.5 (0.9-2.5) | 6.9 (2.8-17.0) |
| MCS ≤40 | 20 (17.9) | 252 (22.8) | 35 (14.5) | 0.8 (0.5-1.3) | 1.5 (0.5-2.9) |
CI, confidence interval; MCS, mental component summary; OR, odds ratio; PCS, physical component summary.
*
Age/sex-adjusted ORs.