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. Author manuscript; available in PMC: 2020 May 22.
Published in final edited form as: Neurobiol Dis. 2019 Oct 24;134:104617. doi: 10.1016/j.nbd.2019.104617

Figure 3. Hippocampal miR-132 overexpression significantly enhances LTP in SH mice and prevents its impairment by soluble Aβ oligomers.

Figure 3.

(A, B) Hippocampal LTP induced by weak HFS (A) or regular HFS (B) in the CA1 region of hippocampal slices from LV-miR132 injected SH mice (red circles, n=7 slices/from 5 mice) vs. LV-control injected SH mice (black diamonds, n=7/4). (C) miR132 overexpression (red diamonds, n=7/4) prevents the ability of soluble Aβ oligomers (7PA2 CM) to impair HFS-induced LTP, whereas the LV-control vector does not (black diamonds, n=6/4). (D) The same as in (C) but using pure, aggregated synthetic Aβ1-42 (LV-control: black circles, n=7/4; LV-mi132: red diamonds, n=7/5). Inset traces are typical fEPSPs recorded before (gray) and after (black, red) HFS for each condition. Horizontal calibration bars: 10 ms; vertical bars: 0.5 mV.