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. Author manuscript; available in PMC: 2020 May 22.
Published in final edited form as: Neurobiol Dis. 2019 Oct 24;134:104617. doi: 10.1016/j.nbd.2019.104617

Figure 6. In vivo injection of a selective HDAC3 inhibitor significantly enhances LTP and prevents LTP impairment by soluble Aβ oligomers.

Figure 6.

(A) Hippocampal LTP induced by a weak HFS stimulation (arrow) in the CA1 region of SH hippocampal slices 48 hr after RGFP-966 icv injection (red circles, n=7 slices/from 5 mice) or vehicle injection (black diamonds, n=7/4). (B) As in (A), but LTP induced by a regular HFS. (C) Effects of soluble human Aβ oligomers (7PA2 CM) on hippocampal LTP induced by HFS in SH brain slices after injection of RGFP-966 (red) or vehicle; (D) As in (C) but using aggregated synthetic Aβ1-42. Inset traces are typical fEPSPs recorded before (gray) and after (black, red) HFS for each condition. Horizontal calibration bars: 10 ms; vertical bars: 0.5 mV.