TABLE 5.
Top 10 KEGG pathways of hub genes in different specific modules.
| #Term | rich_factor | P-value | Example gene | |
| Darkseagreen4 for SYFG | Ribosome | 0.27 | 1.38E-07 | RPL24, RPS17 |
| Cell cycle | 0.22 | 1.15E-05 | CCNE1, ORC5 | |
| mRNA surveillance pathway | 0.24 | 1.77E-04 | RNMT, EIF4A3 | |
| RNA transport | 0.17 | 1.02E-03 | EIF2B5 | |
| Lysosome | 0.18 | 1.42E-03 | ATP6AP1, GNPTG, ENTPD4 | |
| Lysine degradation | 0.24 | 3.33E-03 | SUV39H2, NSD3, NSD2 | |
| DNA replication | 0.25 | 8.18E-03 | MCM3, DNA2, RFC3 | |
| Glycerophospholipid metabolism | 0.16 | 2.06E-02 | PGS1, AGPAT4, AGPAT5 | |
| RNA polymerase | 0.25 | 2.43E-02 | POLR2B, POLR3E | |
| Ribosome biogenesis in eukaryotes | 0.16 | 3.07E-02 | UTP18, LSG1, UTP6 | |
| Brown4 for F6G | Oxocarboxylic acid metabolism | 0.17 | 2.16E-02 | BCAT1, ACO2 |
| Inositol phosphate metabolism | 0.07 | 2.22E-02 | PIKFYVE, PLCD4 | |
| Spliceosome | 0.05 | 2.48E-02 | PRPF40A, PRPF8, THOC2 | |
| Pantothenate and CoA biosynthesis | 0.14 | 2.79E-02 | BCAT1 | |
| Phosphatidylinositol signaling system | 0.05 | 6.14E-02 | PIKFYVE, PLCD4 | |
| Oocyte meiosis | 0.05 | 6.14E-02 | CDC26, PPP1CC, FBXW11 | |
| Biosynthesis of amino acids | 0.06 | 6.21E-02 | BCAT1, MAT2B, ACO2 | |
| Protein processing in endoplasmic reticulum | 0.04 | 6.73E-02 | UGGT1, EDEM1, SEC24D | |
| Citrate cycle (TCA cycle) | 0.08 | 7.25E-02 | ACO2, DLAT | |
| MAPK signaling pathway | 0.03 | 8.75E-02 | PAK2, NFATC3 | |
| Darkred for F1G | Endocytosis | 0.03 | 2.19E-02 | SMAP1, PARD3 |
| Fanconi anemia pathway | 0.05 | 4.04E-02 | POLH | |
| Glycosphingolipid biosynthesis | 0.08 | 7.52E-02 | SialT2 | |
| Inositol phosphate metabolism | 0.03 | 8.64E-02 | ITPKA | |
| Steroid biosynthesis | 0.07 | 1.18E-01 | FDFT1 | |
| Phosphatidylinositol signaling system | 0.02 | 1.50E-01 | ITPKA | |
| Dorsoventral axis formation | 0.05 | 1.58E-01 | CPEB2 | |
| Lysosome | 0.02 | 1.75E-01 | AP1S2 | |
| Tight junction | 0.02 | 1.97E-01 | PRKCD, PARD3 | |
| FoxO signaling pathway | 0.02 | 2.14E-01 | PRKAG2 | |
| Lightgreen for SYFT | Glycosphingolipid biosynthesis | 0.07 | 5.59E-02 | ST3GAL6 |
| Cell cycle | 0.02 | 6.11E-02 | WEE2 | |
| Drug metabolism cytochrome P450 | 0.04 | 9.85E-02 | ||
| Nicotinate and nicotinamide metabolism | 0.04 | 9.85E-02 | NMNAT3 | |
| Metabolism of xenobiotics by cytochrome P450 | 0.04 | 1.02E-01 | ||
| Calcium signaling pathway | 0.01 | 1.05E-01 | ||
| Glutathione metabolism | 0.03 | 1.26E-01 | ||
| Sphingolipid metabolism | 0.03 | 1.36E-01 | SGMS2 | |
| Amino sugar and nucleotide sugar metabolism | 0.02 | 1.49E-01 | GNPDA2 | |
| RNA degradation | 0.02 | 2.09E-01 | BTG4 | |
| Ivory for F6T | Proteasome | 0.29 | 1.33E-08 | PSMB3, PSMB2, PSMC3 |
| Glutathione metabolism | 0.12 | 3.42E-03 | DNTTIP2 | |
| Biosynthesis of unsaturated fatty acids | 0.17 | 4.72E-03 | HACD3 | |
| Ribosome | 0.06 | 6.78E-03 | RPL24, MRPS11, RPL9 | |
| Cell cycle | 0.06 | 9.28E-03 | CDKN1B, MCM6 | |
| RNA degradation | 0.07 | 2.11E-02 | EXOSC8, LSM7, CNOT7 | |
| Spliceosome | 0.05 | 2.48E-02 | SNRPB2, SNRPG, LSM7 | |
| Fatty acid metabolism | 0.08 | 3.17E-02 | HACD3 | |
| Phagosome | 0.04 | 4.42E-02 | STX18, SEC61B, DYNC1I2 | |
| Protein export | 0.11 | 4.63E-02 | SEC61B, SRP72 | |
| Skyblue for F1T | Focal adhesion | 0.09 | 1.78E-08 | MYLK, ITGA8 |
| Regulation of actin cytoskeleton | 0.08 | 4.19E-07 | MYLK, ROCK2 | |
| ECM receptor interaction | 0.13 | 3.65E-06 | COL4A2, ITGA8 | |
| Cardiac muscle contraction | 0.11 | 5.28E-04 | ACTC1, TPM1, TPM3 | |
| Adrenergic signaling in cardiomyocytes | 0.06 | 1.03E-03 | ACTC1, TPM1, MAPK1 | |
| Vascular smooth muscle contraction | 0.07 | 1.30E-03 | MYLK, MRVI1, ROCK2 | |
| Phagosome | 0.05 | 5.06E-03 | ACTB, ITGB1 | |
| Apoptosis | 0.05 | 1.39E-02 | FAS, CTSS, MAPK1 | |
| Cell adhesion molecules (CAMs) | 0.05 | 3.04E-02 | ITGB1, ITGA8, ITGAV | |
| Oocyte meiosis | 0.05 | 3.26E-02 | MAPK1, FBXW11 |
SYF, small yellow follicle; F6, smallest hierarchical follicle; F1, largest hierarchical follicle. G, granulosa cell; T, theca cell.