Table 3.

Effect of acute treatment of studied compounds on the closed arm entries (mean ± SEM) in EPM test in male and female mice.

Drug	Male	Female
vehicle + vehicle	14.42 ± 1.62	16.40 ± 1.33
vehicle + 10 mg/kg NTG	16.29 ± 1.27	15.25 ± 1.28
0.3 mg/kg Ro-64-6198 + vehicle	19.43 ± 1.36	14.62 ± 1.27
0.3 mg/kg Ro-64-6198 + 10 mg/kg NTG	19.29 ± 1.86	15.12 ± 2.03

Mice (7–8 mice/condition) were administered with Ro-64-6198 (0.3 mg/kg), or vehicle 20 min prior to NTG (10 mg/kg) or vehicle and 10 min later the EPM test was conducted.