Table 2.
Effects of medicinal plants and mushroom extracts on the gut microbiota in mouse/rat models of cancer and colitis.
| Plants/mushrooms | Diseases | Enriched gut bacteria | Depleted gut bacteria | References |
|---|---|---|---|---|
| Boswellia serrata Roxb. | Colitis-associated colorectal cancer | Firmicutes (Lachnospiraceae) | Bacteroidetes (Porphyromonadaceae) | Chou et al., 2017 |
| Ganoderma lucidum (Curtis) P. Karst. | Breast cancer | Firmicutes, Proteobacteria (Helicobacter), Rikenella | Acinetobacter, Actinobacteria (Arthrobacter, Corynebacterium), Bacteroidetes (Bacteroides, Parabacteroides, Prevotella), Blautia, Brevundimonas, Clostridium, Coprobacillus, Cyanobacteria, Facklamia, Jeotgalicoccus, Sporosarcina, Staphylococcus, Streptococcus | Su et al., 2018 |
| Ganoderma lucidum (Curtis) P. Karst. | DSS-induced colitis | Firmicutes (Erysipelatoclostridium, Fusicatenibacter, Ruminiclostridium, Ruminococcus), Paraprevotella | Anaerotruncus, Barnesiella, Butyricimonas, Intestinimonas, Proteobacteria (Escherichia-Shigella), Tyzzerella | Xie et al., 2019 |
|
Ganoderma lucidum (Curtis) P. Karst., Gynostemma pentaphyllum (Thunb.) Makino |
Colorectal cancer | Bifidobacterium, Butyricicoccus, Kopriimonas, Mucispirillum, Peptoclostridium, Pseudobutyrivibrio | Acetivibrio, Akkermansia, Alkaliphilus, Anaerobacterium, Anaerostipes, Blautia, Butyrivibrio, Caloramator, Citrobacter, Desulfotomaculum, Eubacterium, Natranaerovirga, Peptococcus, Ruminococcus | Khan et al., 2019 |
| Glycyrrhiza uralensis Fisch. ex DC. | Colorectal cancer | Enterococcus, Enterorhabdus, Odoribacter | Blautia, Parasutterella | Zhang et al., 2018 |
| Hericium erinaceus (Bull.) Pers. | TNBS-induced colitis | Bifidobacterium, Coprococcus, Desulfovibrio, Lactobacillus, Parabacteroides, Prevotella | Corynebacterium, Dorea, Roseburia, Ruminococcus, Staphylococcus, Sutterella | Chen et al., 2017 |
| Hypericum attenuatum Fisch. ex Choisy | DSS-induced colitis | Firmicutes (Clostridiales) | Escherichia-Shigella, Verrucomicrobia (Akkermansia) | Jin et al., 2019 |
| Sanhuang Shu'ai decoction (containing Artemisia argyi H.Lév. and Vaniot, Coptis chinensis Franch., Phellodendron chinense C.K.Schneid., Scutellaria baicalensis Georgi) | DSS-induced colitis | Lactobacillus | — | Wu et al., 2020 |
| Shaoyao Ruangan mixture (containing Agrimonia pilosa Ldb., Ardisia japonica (Thunb.) Blume, Aristolochia mollissima Hance, Citrus reticulate Blanco, Crataegus pinnatifida Bunge, Curcuma phaeocaulis Valeton, Curcuma wenyujin Y.H.Chen and C.Ling, Gardenia jasminoides J. Ellis, Hedyotis diffusa Willd., Imperata cylindrica (L.) P.Beauv., Liquidambar formosana Hance, Lysimachia christinae Hance, Paeonia lactiflora Pall., Paris polyphylla Sm., Scutellaria barbata D.Don, Sparganium stoloniferum (Graebn.) Buch.-Ham. ex Juz., Tetrastigma hemsleyanum Diels and Gilg) | Primary liver cancer | Clostridium cluster XVIII, Desulfovibrio, Turicibacter | Alloprevotella, Bacteroides | Zhen et al., 2019 |
| Yokukansan (containing Angelica acutiloba (Siebold and Zucc.) Kitag., Atractylodes lancea (Thunb.) DC., Bupleurum falcatum L., Cnidium officinale Makino, Glycyrrhiza uralensis Fisch. ex DC., Poria cocos F.A. Wolf, Uncaria rhynchophylla (Miq.) Miq.) | Lung cancer | Bacteroidales, Desulfovibrionaceae | — | Han et al., 2019 |
DSS, dextran sulfate sodium; TNBS, trinitrobenzenesulfonic acid.