Table 1.
miR-126 target genes by in silico analysis
| miR-126-5p target genes | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Top-10 miR-126-5p target genes | Cell cycle | Cell morphology | Lipid metabolism | Cellular movement | Cellular assembly and organization | Cellular development | Cellular growth and proliferation | Cell-to-cell signalling and interaction | Total score | MFE values | ||
| HGF | 2 | 9 | 1 | 9 | 3 | 8 | 1 | 7 | 40 | −9.4 | ||
| IL6 | 6 | 4 | 0 | 2 | 3 | 10 | 2 | 2 | 29 | −12.5 | −13.3 | |
| CD44 | 2 | 4 | 0 | 7 | 0 | 5 | 1 | 4 | 23 | −12.6 | −9.6 | −12.5 |
| ADIPOQ | 1 | 1 | 0 | 2 | 4 | 5 | 3 | 1 | 17 | −8.9 | ||
| BDNF | 0 | 4 | 0 | 4 | 3 | 4 | 0 | 1 | 16 | −9.7 | ||
| BCL2 | 3 | 4 | 0 | 0 | 0 | 3 | 3 | 1 | 14 | −13.1 | −14 | |
| NRG1 | 3 | 0 | 0 | 2 | 3 | 5 | 0 | 1 | 14 | −11 | ||
| HIF1A | 4 | 0 | 0 | 3 | 0 | 5 | 0 | 0 | 12 | −8.3 | −11.2 | −12.6 |
| ITGA4 | 0 | 2 | 0 | 6 | 3 | 0 | 0 | 1 | 12 | −12.1 | −8.5 | −13.1 |
| MAD2L1 | 9 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 12 | −17.9 | ||
| P-value | 0.000046 | 0.000048 | 0.000295 | 0.000597 | 0.000756 | 0.00179 | 0.00179 | 0.00197 | −10.9 | |||
The potential target genes for miR-126-5p related with the top 10 cellular functions by core analysis, a tool from IPA (Ingenuity Pathway Analysis). The cellular functions are showed by P-values according to score. Minimum Free Energy (MFE) values were obtained by RNAhybrid. Bold HIF1α MFE highlighted in bold.