Table 3.

Multivariable linear mixed model analyses of factors associated with CD4 changes overtime among HIV-infected children-initiated ART Amhara region public hospitals (2010–2016)

Covariate	Estimate	95% CI
Constant	2.494	2.328	2.660
Time	0.008	0.007	0.009
BMI	0.005	− 0.003	0.012
Age	− 0.015	− 0.021	− 0.009
Hemoglobin	0.013	0.004	0.022
BWHO stage
Stage I	0
Stage II	− 0.046	− 0.091	− 0.0003
Stage III	− 0.039	− 0.089	0.011
Stage IV	− 0.053	− 0.149	0.043
Opportunistic infection
Yes	− 0.044	− 0.0845	− 0.0042
No	0
Functional status
Working	0
Ambulatory	0.004	− 0.036	0.044
Bedridden	0.008	− 0.209	0.225
Disclosure
Yes	− 0.087	− 0.129	0.046
No	0
Mothers ARV status
Yes	0.055	− 0.019	0.128
No	0
Regimen type
d4T + 3TC + NVP	0
d4T + 3TC + EFV	− 0.143	− 0.217	0.068
AZT + 3TC + NVP	0.022	− 0.020	0.064
AZT + 3TC + EFV	0.070	− 0.017	0.123
TDF + 3TC + EFV	0.170	− 0.010	0.330
Others*	0.157	− 0.004	0.310

*TDF + 3TC + EFV, AZT + 3TC + LPV/r, ABC + 3TC + LPV/r