Table 3.
Prognostic factors associated with overall survival in patients with endometrial carcinoma with cervical involvement (N = 239)
| Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p | HR | 95% CI | p | |
| Age | 1.01 | 0.98–1.04 | 0.461 | |||
| Age > 45 years | 1.57 | 0.69–3.55 | 0.284 | |||
| BMI | 1.01 | 0.95–1.06 | 0.717 | |||
| Obesity (BMI > 30) | 1.21 | 0.64–2.28 | 0.560 | |||
| BPH | 2.34 | 1.25–4.43 | < 0.001 | 0.94 | 0.38–2.26 | 0.887 |
| Tumor size, mm | 0.99 | 0.98–1.001 | 0.587 | |||
| Tumor size > 4 cm | 1.01 | 0.38–2.83 | 0.991 | |||
| Grade 1-2 vs. 3-BPH | 4.49 | 2.19–9.22 | < 0.001 | 3.39 | 1.16–9.92 | 0.026 |
| LVI | 2.18 | 1.15–4.12 | 0.017 | 0.52 | 0.21–1.27 | 0.152 |
| Myometrial involvement >50% | 2.54 | 1.12–5.79 | 0.026 | 0.97 | 0.35–2.68 | 0.958 |
| Depth of invasion | 1.01 | 0.97–1.05 | 0.660 | |||
| Depth invasion/thickness rate | 0.70 | 0.15–3.18 | 0.646 | |||
| Ovarian involvement | 1.69 | 0.83–3.47 | 0.148 | |||
| Parametrial involvement | 1.61 | 0.49–5.22 | 0.432 | |||
| Uterine serosa involvement | 1.43 | 0.51–4.02 | 0.495 | |||
| Pelvic node involvement | 2.03 | 0.96–4.29 | 0.064 | 1.16 | 0.48–2.78 | 0.740 |
| Para-aortic node involvement | 1.87 | 0.82–4.28 | 0.136 | |||
| Distant disease | 2.38 | 1.04–5.45 | 0.039 | 0.98 | 0.31–3.18 | 0.986 |
| Radical hysterectomy | 0.73 | 0.29–1.87 | 0.515 | |||
| Radiotherapy | 0.32 | 0.16–0.63 | 0.001 | 0.12 | 0.04–0.39 | < 0.001 |
| Chemotherapy | 2.06 | 1.04–4.07 | 0.037 | 3.74 | 1.16–12.09 | 0.027 |
HR hazard ratio, 95% CI 95% confidence interval, BMI body mass index, BPH bad prognostic histology (serous papillary, clear cell, mixed, carcinosarcoma), LVI lymphovascular invasion