Table 4.

Prognostic factors associated with disease-free survival in patients with endometrial carcinoma with cervical affection (N = 239)

	Univariate			Multivariate
	HR	95% CI	p	HR	95% CI	p
Age	1.03	1.01–1.05	0.012
Age > 45 years	2.91	1.24–6.81	0.014	5.50	0.94–32.00	0.060
BMI	1.02	0.97–1.06	0.578
Obesity (BMI > 30)	1.29	0.78–2.18	0.350
BPH	2.47	1.45–4.19	0.001	0.89	0.24–3.31	0.867
Tumor size, mm	0.99	0.98–0.99	0.047	0.98	0.96–0.99	0.031
Tumor size > 4 cm	0.72	0.34–1.53	0.395
Grade 1–2 vs. 3–BPH	3.01	1.73–5.23	< 0.001	2.92	0.62–13.64	0.171
LVI	2.62	1.51–4.52	0.001	0.38	0.98–1.53	0.98
Myometrial involvement > 50%	2.33	1.20–4.52	0.012	2.64	0.52–13.33	0.239
Depth of invasion	0.97	0.92–1.02	0.238
Depth invasion/thickness rate	0.77	0.24–2.49	0.658
Ovarian involvement	2.67	1.53–4.67	0.001	0.61	0.14–2.61	0.503
Parametrial involvement	2.91	1.24–6.83	0.014	13.20	0.78–222.04	0.073
Uterine serosa involvement	2.05	0.92–4.54	0.077	0.13	0.001–1.44	0.096
Pelvic node involvement	1.66	0.88–3.12	0.112	2.23	0.56–8.84	0.253
Para-aortic node involvement	1.73	0.88–3.39	0.110	1.67	0.47–5.93	0.426
Distant disease	4.90	2.61–9.21	< 0.001	1.22	0.28–5.32	0.783
Radical hysterectomy	1.23	0.64–2.38	0.535
Radiotherapy	0.29	0.16–0.54	< 0.001	0.116	0.02–0.59	0.001
Chemotherapy	3.36	1.77–6.37	< 0.001	7.86	1.21–51.24	0.031

HR hazard ratio, 95% CI 95% confidence interval, BMI body mass index, BPH bad prognostic histology (serous papillary, clear cell, mixed, carcinosarcoma), LVI lymphovascular invasion