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. 2020 May 22;19:94. doi: 10.1186/s12943-020-01207-4

Fig. 2.

Fig. 2

Association between m6A and miRNAs on 3′-UTRs of mRNAs. (A) m6A is more common on 3′-UTRs of mRNAs containing miRNA target sites. m6A is mostly deposited near the stop codon, whereas miRNA target sites are generally enriched in 3′ end of 3′-UTRs (B) m6A may regulate the binding and gene silencing function of the downstream-bound miRNAs. (C) miRNAs promote METTL3-mediated m6A formation on mRNAs through a sequence pairing mechanism