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. 2020 May 15;11:415. doi: 10.3389/fphys.2020.00415

TABLE 3.

Neonatal and maternal characteristics of live born singletons.

Characteristics GQE of cleavage (n = 922) PQE of cleavage (n = 175) GQE of blastocyst (n = 932) PQE of blastocyst (n = 374) P-valuea P-valueb
Gestational age (weeks)
 <32 weeks 5(0.5) 3(1.7) 6(0.6) 4(1.1) 0.121 0.485
 32–36 weeks 53(5.7) 16(9.2) 63(6.8) 26(7.0) 0.090 0.901
 ≥37 weeks 864(93.7) 156(89.1) 863(92.6) 344(92.0) 0.030 0.703
Mode of delivery (%) 0.040 0.407
 Vaginal 203(22.0) 51(29.1) 219(23.5) 96(25.7)
 Caesarean section 719(78.0) 124(70.9) 713(76.5) 278(74.3)
Sex (%) 0.794 <0.001
 Male 459(49.8) 89(50.9) 556(59.7) 187(50.0)
 Female 463(50.2) 86(49.1) 376(40.3) 187(50.0)
Birthweight (g)d 3295.5 ± 478.5 3279.8±545.1 3386.5 ± 492.5 3330.4±498.9 0.722 0.004
 Z-score 0.26 ± 1.03 0.27 ± 0.99 0.51 ± 1.04 0.35 ± 1.10 0.889 0.011
 2500–4500 gc 887(96.2) 161(92.0) 898(96.4) 346(92.5) 0.014 0.003
 VLBW(<1500 g) 5(0.5) 2(1.1) 6(0.6) 3(0.8) 0.310 0.721
 LBW(<2500g)c 29(3.1) 14(8.0) 25(2.7) 22(5.9) 0.002 0.005
 HBW(>4500 g) 6(0.7) 1(0.6) 9(1.0) 6(1.6) 0.904 0.489
SGA(<10th percentile) 60(6.5) 7(4.0) 33(3.5) 22(5.9) 0.204 0.057
VSGA(<3th percentile) 16(1.7) 3(1.7) 7(0.8) 7(1.9) 0.984 0.139
LGA(>90th percentile) 135(14.6) 21(12.0) 207(22.2) 71(19.0) 0.359 0.198
VLGA(>97th percentile) 43(4.7) 10(5.7) 82(8.8) 26(7.0) 0.552 0.273
Congenital 9(1.0) 3(1.7) 9(1.0) 7(1.9) 0.420 0.176
malformations (%)
Neonatal 45(4.9) 9(5.1) 39(4.2) 23(6.1) 0.883 0.131
Complications (%)
Maternal
Complications (%)
 GDM 102(11.0) 17(9.7) 98(10.5) 51(13.6) 0.599 0.109
 PPROM 12(1.3) 5(2.9) 15(1.6) 9(2.4) 0.170 0.332
 Placenta previa 28(3.0) 5(2.9) 21(2.3) 17(4.5) 0.898 0.026
 PIH 31(3.4) 4(2.3) 27(2.8) 9(2.4) 0.485 0.624
 Pre-eclampsia 17(1.8) 3(1.7) 14(1.5) 7(1.9) 0.907 0.631
 Post-partum haemorrahage 15(1.6) 4(2.3) 17(1.8) 5(1.3) 0.527 0.536

GDM = gestational diabetes; PPROM = preterm premature rupture of membranes; PIH = pregnancy-induced hypertension; Data are presented as mean (±SD) or median (interquartile range) according to if variables were normally distributed or not. Continuous variables were compared using t-test or Mann–Whitney–Wilcoxon tests, and categorical variables were presented as numbers (%) and evaluated with chi-squared tests. aP-value for PQE of cleavage vs GQE of cleavage. bP-value for GQE of blastocyst vs GQE of blastocyst. cP-value < 0.001 for PQE vs GQE in all singletons. dP-value = 0.045 for PQE vs GQE in all singletons.