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Comparison of NONMEM® ODE solvers to AutoKinetics.
| NONMEM® ODE solver | Median difference in calculated concentration (mg/L) between NONMEM® and AutoKinetics |
|---|---|
| Analytical solution ADVAN 1 (suited for one compartment models) | 0.0003344 (0.0001289–0.0007203) |
| Approximate solution ADVAN 6 (most commonly used ODE solver) | 0.0101345 (0.0059696–0.0174771) |
| Approximate solution ADVAN13 (LSODA method) | 0.0100327 (0.0058412–0.0174159) |
