. 2020 May 15;11:646. doi: 10.3389/fphar.2020.00646

Table 3.

Implemented PK models for ICU Patients.

Antibiotic	Model	Pubmed ID	CMT	CL	V1	Q1	V2	IIV	Residual error	Software	Algorithm	COVARIATES
Meropenem	Muro 2011 n=68	21366653	1	11.1 L/h	33.6 L	NA	NA	Exponential	Add	NONMEM	FO	$C L = θ_{C L} \times {(\frac{m S C R}{0.7})}^{θ_{m S C E_C L}}$
												θ _CL=11.1 θ _{mSCR_CL} =−1 (if SCR < 0.4 mg/dL, mSCR=0.4)
												θ _CL=11.1 θ _{mSCR_CL} =−1 (if SCR < 0.4 mg/dL, mSCR=0.4)
Ciprofloxacin	Khachman	21653603	2	18 L/h	38 L	60 L/h	73 L	Exponential	Prop	NONMEM	FOCE+I	$C L = θ 1 \times {(C L_{C r C o c k c r o f t} / 91.7)}^{θ 2}$
	2011
	n=102
Ceftriaxone	Garot 2011 n=54	21545483	2	0.56 L/h	10.3 L	5.28 L/h	7.35 L/h	Exponential	Prop	NONMEM	FOCE	$C L = θ_{C L} + θ_{C L C r} \times \frac{C L c r}{4.26} Cockcroft - Gault (as instead)$
												θ CL = 0.56 θ _CLCr = 0.32
												θ CL = 0.56 θ _CLCr = 0.32
Vancomycine	Roberts 2011 N=206	21402850	1	4.58 L/h	1.53 L/kg	NA	NA	Exponential	Add, Prop	NONMEM	FOCE+I	$C L = θ_{C L} \times \frac{C L_{c r}}{100}$
												θ _CL = 4.58
												V1 = θ _V1 × BW θ _V1 = 1.53

Add, Additive residual error; CL, Clearance of central compartment; CMT, Number of compartments; FO, First order estimation; FOCE, First order conditional estimation; IIV, Inter individual variability; n, Number of patient used for model development; NA, Not applicable; NCA, Non compartmental analysis; NPAG, Non Parametric Adaptive Grid; Prop, Proportional residual error; Q1, Inter-compartmental clearance between central and peripheral compartments; V1, Volume of distribution of central compartment; V2, Volume of distribution of peripheral compartment.