Figure 7:

Schematic summarizing the effects of gestational BPA treatment during early, mid and late gestation. The light blue shaded area represents the period of BPA treatment spanning early to mid-gestation (gestational day 30–90; term ~147 days). Outcomes evident during this period may be due to direct effects of BPA or indirectly mediated by the changes in steroid input – function of changes in steroidogenic enzymes and steroid receptors, epigenetic machinery and mediators of placental function. Outcomes extending into late gestation likely represent the latent effects induced by BPA during early- / mid-gestation and programmed through changes in steroidal and epigenetic changes. Significant changes are shown in brown shaded areas with white letters and non-significant large magnitude effects as determined by Cohens effect size analysis are shown in orange shaded areas with black letters.