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. 2020 May 15;11:483. doi: 10.3389/fgene.2020.00483

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Copyright © 2020 Mead, Roe, Higgins Keppler, Van Dyke, Laux, Funke, Miller, Bean, Sahl and Barker.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Venn diagram of differentially expressed genes between mycelia and spherules for each strain, respectively. Diagram shows genes that change expression in spherules compared to mycelia for the wild-type and mutant strain. Genes were included if expression was significantly (FDR p < 0.05) up-regulated (solid oval) or down-regulated (striped oval) twofold or more. Of interest are 259 gene transcripts that in the mutant deviate from the pattern of the wild-type parent: 19 genes up-regulated in the wild-type parasitic lifecycle and down in the mutant, 18 down-regulated in the wild-type parasitic lifecycle and up in the mutant, and 222 up regulated only in the wild-type lifecycle. Of these 259 genes, the asterisk (*) indicates that seven are unique to Coccidioides.