FIGURE 4.

Gene description and heatmap of 19 improperly down-regulated genes. When comparing wild-type mycelia to spherules, these genes are significantly up-regulated. However, they are down-regulated in the mutant spherules compared to mycelia. (A) Table of the 19 genes and product descriptions, some of which have been shown to be important in stress response, pH, and metal ion acquisition in other fungi. When genes were annotated as hypothetical the asterisk (*) indicates ortholog function in other fungi. (B) Heatmap visualization in log₁₀FPKM of the opposing expression patterns for wild-type and mutant lifecycle. A darker color indicates increased expression while lighter indicates decreased expression measured in log₁₀ FPKM.