Table 2.
Adjusted Changes and 95% CIs in Predicted Global Cognitive Functioning, Delayed and Immediate Word Recall, and Working Memory With Incident Multimorbidity for Each 1-Point Increase in the Multimorbidity-Weighted Index, 2000–2014
| TICSm | Delayed word recall | Immediate word recall | Serial 7s test | |||||
|---|---|---|---|---|---|---|---|---|
| Model 1 Regression coefficient (95% CI) p-value |
Model 2 Regression coefficient (95% CI) p-value |
Model 1 Regression coefficient (95% CI) p-value |
Model 2 Regression coefficient (95% CI) p-value |
Model 1 Regression coefficient (95% CI) p-value |
Model 2 Regression coefficient (95% CI) p-value |
Model 1 Regression coefficient (95% CI) p-value |
Model 2 Regression coefficient (95% CI) p-value |
|
| Time | −0.21 (−0.21, −0.20) p < .001 |
−0.18 (−0.20, −0.18) p < .001 |
−0.08 (−0.09, −0.08) p < .001 |
−0.08 (−0.08, −0.08) p < .001 |
−0.07 (−0.08, −0.07) p < .001 |
−0.05 (−0.07, −0.06) p < .001 |
−0.03 (−0.03, −0.03) p < .001 |
−0.03 (−0.03, −0.02) p < .001 |
| Multimorbidity-weighted index | −0.034 (−0.043, −0.029) p < .001 |
−0.015 (−0.025, −0.006) p = .002 |
−0.014 (−0.018, −0.011) p < .001 |
−0.011 (−0.016, −0.006) p < .001 |
−0.014 (−0.016, −0.011) p < .001 |
−0.006 (−0.010, −0.002) p = .002 |
−0.009 (−0.012, −0.007) p < .001 |
−0.002 (−0.006, 0.002) p = .36 |
| MWI * Time | N/A | −0.003 (−0.004, −0.002) p < .001 |
N/A | −0.001 (−0.001, 0.000) p = .06 |
N/A | −0.001 (−0.002, −0.001) p < .001 |
N/A | −0.001 (−0.002, −0.001) p < .001 |
| Age | −0.13 (−0.13, −0.12) p < .001 |
−0.13 (−0.13, −0.12) p < .001 |
−0.07 (−0.07, −0.07) p < .001 |
−0.07 (−0.07, −0.07) p < .001 |
−0.06 (−0.06, −0.05) p < .001 |
−0.06 (−0.06, −0.05) p < .001 |
−0.02 (−0.02, −0.01) p < .001 |
−0.02 (−0.02, −0.02) p < .001 |
| Intercept | 15.08 (14.64, 15.53) p < .001 |
15.02 (14.58, 15.47) p < .001 |
6.71 (6.52, 6.91) p < .001 |
6.71 (6.51, 6.90) p < .001 |
6.71 (6.54, 6.88) p < .001 |
6.69 (6.52, 6.86) p < .001 |
2.63 (2.47, 2.78) p < .001 |
2.61 (2.46, 2.76) p < .001 |
| Log likelihood | −186536.1 | −186518.4 | −137414.5 | −137412.7 | −124727.5 | −124716.2 | −117160.6 | −117146.7 |
Notes: N = 14,265 participants, n = 73,700 observations.
CI = confidence interval; MWI = multimorbidity-weighted index; N/A = not applicable; TICSm = Telephone Interview for Cognitive Status, modified.
Model 1: MWI, covariates (age (years), sex, race/ethnicity (white, black, Hispanic, other), education (<12, 12, 13–15, ≥16 years, household net wealth (≤$14,000, $14,001–$113,000, $113,001–$323,700, ≥$323,701), marital status/living arrangement (married or living with partner, living with someone other than partner, living alone), BMI (<18.5, 18.5–24.9, 25–29.9, ≥30 kg/m2, smoking status (never, past, current), alcohol use (never, former, 1 drink/week, >1 drink/week), physical activity (≥1 vigorous physical activity/week), years since baseline), respective cognitive functioning measure at baseline.
Model 2: additionally adjusted for interaction between MWI and time.