Table 3.
Comparison Between the Standardized Multimorbidity-Weighted Index and Simple Disease Count for Multimorbidity and Adjusted Changes in Global Cognitive Functioning, Delayed and Immediate Word Recall, and Working Memory, Health and Retirement Study, 2000–2014
| TICSm | Delayed word recall | Immediate word recall | Serial 7s test | |||||
|---|---|---|---|---|---|---|---|---|
| MWI Regression coefficient (95% CI) p-value |
Disease count Regression coefficient (95% CI) p-value |
MWI Regression coefficient (95% CI) p-value |
Disease count Regression coefficient (95% CI) p-value |
MWI Regression coefficient (95% CI) p-value |
Disease count Regression coefficient (95% CI) p-value |
MWI Regression coefficient (95% CI) p-value |
Disease count Regression coefficient (95% CI) p-value |
|
| Time | −0.18 (−0.20, −0.18) p < .001 |
−0.18 (−0.19, −0.17) p < .001 |
−0.08 (−0.08, −0.08) p < .001 |
−0.08 (−0.08, −0.07) p < .001 |
−0.06 (−0.07, −0.06) p < .001 |
−0.06 (−0.07, −0.06) p < .001 |
−0.03 (−0.03, −0.02) p < .001 |
−0.02 (−0.03, −0.02) p < .001 |
| Multimorbidity−Weighted Index | −0.083 (−0.135, −0.031) p = .002 |
N/A | −0.060 (−0.086, −0.033) p <.001 |
N/A | −0.035 (−0.057, −0.013) p = .002 |
N/A | −0.002 (−0.006, 0.002) p = .36 |
N/A |
| MWI * Time | −0.018 (−0.024, −0.012) p < .001 |
N/A | −0.003 (−0.010, 0.000) p = .06 |
N/A | −0.006 (−0.009, −0.004) p < .001 |
N/A | −0.001 (−0.002, −0.001) p < .001 |
N/A |
| Disease count | N/A | −0.068 (−0.120, −0.016) p = .01 |
N/A | −0.060 (−0.085, −0.033) p < .001 |
N/A | −0.031 (−0.053, −0.010) p = .004 |
N/A | −0.001 (−0.021, 0.019) p = .92 |
| Disease count*Time | N/A | −0.020 (−0.026, −0.014) p < .001 |
N/A | −0.003 (−0.006, −0.000) p = .03 |
N/A | −0.006 (−0.009, −0.004) p < .001 |
N/A | −0.007 (−0.009, −0.005) p < .001 |
| Age | −0.13 (−0.13, −0.12) p < .001 |
−0.13 (−0.13, −0.12) p < .001 |
−0.07 (−0.07, −0.07) p < .001 |
−0.07 (−0.07, −0.06) p < .001 |
−0.06 (−0.06, −0.05) p < .001 |
−0.06 (−0.06, −0.05) p < .001 |
−0.02 (−0.02, −0.02) p < .001 |
−0.02 (−0.02, −0.02) p < .001 |
| Intercept | 15.02 (14.58, 15.48) p < .001 |
14.98 (14.53, 15.42) p < .001 |
6.71 (6.51, 6.90) p < .001 |
6.69 (6.49, 6.89) p < .001 |
6.69 (6.52, 6.86) p < .001 |
6.67 (6.51, 6.84) p < .001 |
2.61 (2.46, 2.76) p < .001 |
2.60 (2.45, 2.75) p < .001 |
| Log likelihood | −186518.3 | −186522.6 | −137412.7 | 137413.7 | −124716.2 | −124725.3 | −117146.7 | −117147.0 |
| AIC | 373098.8 | 373107.2 | 274887.4 | 274889.4 | 249494.3 | 249512.5 | 234355.3 | 234356.0 |
Notes: N = 14,265 participants, n = 73,700 observations.
AIC = Akaike Information Criterion; CI = confidence interval; MWI = multimorbidity-weighted index; N/A = not applicable; TICSm = Telephone Interview for Cognitive Status, modified.
Adjusted for age, sex, race/ethnicity, education, household net wealth, marital status/living arrangement, BMI, smoking status, alcohol use, physical activity, years since baseline, respective cognitive functioning measure at baseline, and interaction between multimorbidity metric and time