Table 2.
Least-Squares Means (95% Confidence Interval) of SM-MMSE Score by Quartiles of Riboflavin and Folate Intake in the Singapore Chinese Health Study (n = 16,948)
| SM-MMSE score | ||||
|---|---|---|---|---|
| Least-squares means (95% CI) | β | p Value | p Trend | |
| Riboflavin | <.001 | |||
| Q1 | 24.18 (23.73, 24.64) | |||
| Q2 | 24.27 (23.82, 24.72) | 0.09 | .23 | |
| Q3 | 24.52 (24.07, 24.97) | 0.34 | <.001 | |
| Q4 | 24.49 (24.04, 24.93) | 0.30 | <.001 | |
| Folate | .003 | |||
| Q1 | 24.18 (23.72, 24.63) | |||
| Q2 | 24.41 (23.96, 24.86) | 0.23 | .002 | |
| Q3 | 24.40 (23.95, 24.85) | 0.22 | .005 | |
| Q4 | 24.48 (24.03, 24.93) | 0.31 | <.001 |
Note: Linear trend was tested by treating the median values of quartiles as a continuous variable; The statistical model was the same as the multivariate model with other B vitamins in Figure 1; , SM-MMSE = Singapore-modified version of Mini-Mental State Examination; Q = quartile.