Table 1.
Clinical high risk for psychosis criteria
| Ultra-high risk (UHR) criteria as per the Structured Interview for Psychosis-Risk Syndromes (SIPS) and basic symptom (BS) criteria as per the Schizophrenia Proneness Instruments (SPI-A/SPI-CY)[15,16] |
| UHR: Brief Intermittent Psychotic Symptoms Syndrome (BIPSS) |
| ≥ 1 of the following SIPS positive (P) items scored 6 = “severe and psychotic” with first appearance in the past 3 months and a presence of at least several minutes per day at a frequency of at least once per month but less than 7 d: |
| P1 Unusual Thought Content/Delusional Ideas |
| P2 Suspiciousness/Persecutory Ideas |
| P3 Grandiose Ideas |
| P4 Perceptual Abnormalities/Hallucinations |
| P5 Disorganized Communication |
| UHR: Attenuated Psychotic Symptoms Syndrome (APSS) |
| ≥ 1 of the above P-items scored 3 = “moderate” to 5 = “severe but not psychotic” with a first appearance within the past year or current rating one or more scale points higher compared to 12 mo ago, and with an occurrence of an average frequency of at least once per week in the past month. |
| UHR: Genetic Risk and Deterioration Syndrome (GRDS) |
| Patient meets SIPS-criteria for Schizotypal Personality Disorder or has 1st-degree relative with a psychotic disorder, and has experienced > 30% drop in the global assessment of functioning score over the last month compared to 12 mo ago |
| BS: Cognitive-Perceptive Basic Symptoms (COPER) |
| ≥ 1 of the following BS with a score of ≥ 3 = “frequency of at least several times in a month or weekly” within the last 3 mo and with first occurrence ≥ 12 mo ago: |
| Thought interference |
| Thought perseveration |
| Thought pressure |
| Thought blockages |
| Disturbance of receptive speech |
| Decreased ability to discriminate between ideas/perception, fantasy/memories |
| Unstable ideas of reference |
| Derealization |
| Visual perception disturbances (excl. hypersensitivity to light or blurred vision) |
| Acoustic perception disturbances (excl. hypersensitivity to sounds) |
| BS: Cognitive Disturbances (COGDIS) |
| ≥ 2 of the following BS with a score of ≥ 3 within the last 3 mo: |
| Inability to divide attention |
| Thought interference |
| Thought pressure |
| Thought blockages |
| Disturbance of receptive speech |
| Disturbance of expressive speech |
| Unstable ideas of reference |
| Disturbances of abstract thinking |
| Captivation of attention by details of the visual field |