Table 2.

Various clinical associations of pediatric hepatocellular adenomas

Sex hormone dysregulation

Oral contraceptive use

Obesity

Klinefelter’s syndrome

Polycystic ovary syndrome

Sex hormone producing tumours (e.g., ertoli-Leydig cell tumours)

Androgen therapy (Turner’s syndrome, Fanconi anemia, Glanzmann's thrombasthenia)

Antiepileptic therapies with sodium ion channel modulation

Metabolic disorders

Glycogen storage diseases type I, III, and IV

Galactosemia

Hurler syndrome (mucopolysaccharidosis type 1)

Fanconi Anemia (with or without androgen therapy)

Diabetes mellitus type II

Immunodeficiency

Congenital portosystemic shunts

Cardiac hepatopathy (status-post Fontan procedure)

Other syndromes

Alagille syndrome

Familial adenomatous polyposis syndrome

Maturity-onset diabetes of the young type 3

McCune-Albright syndrome

Noonan syndrome with multiple lentigines

Prader Willi syndrome

Wolf-Hirschhorn syndrome