Table II:
Top SNPs from within COGA meta analysis (N = 10,842)
| RSID | CHR | Dir. | Meta B | Meta SE | Meta P | AA B | AA SE | AA P | AA MAF | EA B | EA SE | EA P | EA MAF |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs2376620 | 6 | -- | −0.050 | 0.008 | 3.91E-09 | 0.035 | 0.013 | 9.11E-03 | 0.242 | 0.059 | 0.011 | 2.43E-08 | 0.148 |
| rs2433198 | 15 | -- | −0.035 | 0.006 | 1.78E-08 | 0.040 | 0.011 | 2.86E-04 | 0.467 | 0.033 | 0.007 | 8.75E-06 | 0.450 |
| rs12928255 | 16 | ++ | 0.039 | 0.007 | 1.93E-08 | −0.031 | 0.014 | 2.44E-02 | 0.218 | −0.042 | 0.008 | 1.26E-07 | 0.381 |
| rs10149887 | 14 | ++ | 0.074 | 0.014 | 1.23E-07 | 0.076 | 0.017 | 7.80E-06 | 0.114 | 0.068 | 0.023 | 2.90E-03 | 0.037 |
| rs8135590 | 22 | ++ | 0.038 | 0.007 | 1.92E-07 | 0.029 | 0.015 | 5.63E-02 | 0.182 | 0.040 | 0.008 | 6.50E-07 | 0.358 |
| rs72884541 | 6 | -? | −0.155 | 0.030 | 2.19E-07 | 0.155 | 0.030 | 1.53E-07 | 0.037 | - | - | - | - |
| rs1901817 | 16 | ++ | 0.036 | 0.007 | 3.21E-07 | 0.039 | 0.013 | 3.72E-03 | 0.240 | 0.035 | 0.008 | 1.63E-05 | 0.313 |
EA = European ancestry; AA = African ancestry; Meta = METAL inverse variance fixed effects results
CHR = Chromosome; Dir. = direction of association effect in AA (left) and EA (right); B = beta; SE = standard error; P = p value