Table IV:
Polygenic Score Prediction in Validation Sample
PGS P-Value Threshold | European Ancestry (N = 2,761) | African Ancestry (N = 1,175) | ||||||
---|---|---|---|---|---|---|---|---|
Beta | SE | P | R2 (%) | Beta | SE | P | R2 (%) | |
p < .0001 | −0.010 | 0.012 | 0.391 | 0.026% | 0.012 | 0.017 | 0.479 | 0.042% |
p < .001 | 0.007 | 0.012 | 0.560 | 0.012% | 0.027 | 0.017 | 0.125 | 0.197% |
p < .01 | 0.008 | 0.012 | 0.505 | 0.016% | 0.011 | 0.018 | 0.549 | 0.030% |
p < .05 | 0.018 | 0.012 | 0.134 | 0.081% | 0.014 | 0.018 | 0.419 | 0.055% |
p < .10 | 0.029 | 0.012 | 0.018 | 0.203% | 0.010 | 0.018 | 0.581 | 0.025% |
p < .20 | 0.015 | 0.012 | 0.214 | 0.055% | 0.016 | 0.018 | 0.377 | 0.065% |
p < .30 | 0.012 | 0.012 | 0.314 | 0.036% | 0.015 | 0.018 | 0.401 | 0.059% |
p < .40 | 0.014 | 0.012 | 0.254 | 0.047% | 0.009 | 0.018 | 0.622 | 0.020% |
p < .50 | 0.013 | 0.012 | 0.281 | 0.042% | 0.010 | 0.018 | 0.583 | 0.025% |
Bolded estimates indicates p < .05. All models include age, sex, and within-ancestry principal components as covariates.