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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Acta Neuropathol. 2019 Oct 29;139(1):157–174. doi: 10.1007/s00401-019-02086-w

Fig 6. Atm heterozygosity increases neurofibroma number.

Fig 6.

(a) Schematic of generation of neurofibroma mice breeding with or without Atm heterozygosity. (b) Volumetric measurements of MRI scans of mice at 4 months of age. (n=6 Nf1 fl/fl; DhhCre, n=6 Atm+/−; Nf1 fl/fl; DhhCre). Tumor volume was increased in Atm+/−; Nf1 fl/fl; DhhCre mice. Un-paired t-test, *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001 (c) Representative images of gross dissections of spinal cords attached to peripheral nerves and tumors from mice at 7 months of age. (d, e) Statistical analysis (n=8 mice, Nf1 fl/fl; DhhCre, n=11 mice, Atm+/−; Nf1 fl/fl; DhhCre, at 7 months of age. (d) Tumor number/mouse, unpaired t-test. (e)Tumor diameter: Nf1 fl/fl; DhhCre mouse total of 30 tumors and Atm+/−; Nf1 fl/fl; DhhCre total of 102 tumors, unpaired t-test.